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  7. G alpha 15 Stable Cell Line-MT1-CHO-K1-Human(Currently Unavailable)

G alpha 15 Stable Cell Line-MT1-CHO-K1-Human(Currently Unavailable)

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Figure 1: Functional analysis of MT1 receptor.

G alpha 15 Stable Cell Line-MT1-CHO-K1-Human(Currently Unavailable)

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Product code: 14-6157ACL

Application : Functional Assay
Reactivity : Human

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Amount : 2 vials
Content : Each Vial contains cells in 45% culture medium, 45% FBS, 10% DMSO
Storage condition : Immediately upon receipt, store in liquid nitrogen.
Alternative Name : Human Recombinant Melatonin MT1 Receptor Stable Cell Line
Melatonin binds to two specific G-protein coupled receptors (GPCR), MT1 (MTNR1A/MEL1A) and MT2 (MTNR1B/MEL1B). MT1 receptors signal via inhibitory G proteins (G alpha i and G alpha o) leading to adenylate cyclase inhibition and possibly inositol phosphate stimulation in recombinant systems. In certain native tissues (e.g. sheep pars tuberalis, rat cerebral and caudal arteries) melatonin responses are presumably mediated through activation of MT1 receptors. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin.

Application: Screen for antibodies through Flow Cytometry, Immunocytochemistry or Western blotting and analyzing receptors.
Culture Medium: Ham's F12, 10% FBS, 200 µg/ml Zeocin, 100 µg/ml Hygromycin B

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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G alpha 15 Stable Cell Line-MT1-CHO-K1-Human(Currently Unavailable)

Product code: 14-6157ACL
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