Anti-DOG-1 / TMEM16A (Gastrointestinal Stromal Tumor Marker) Monoclonal Antibody(Clone: DG1/1486)

Name: Anti-DOG-1 / TMEM16A (Gastrointestinal Stromal Tumor Marker) Monoclonal Antibody(Clone: DG1/1486)
Brand: Abeomics
SKU: 36-2989
Price: 520.0000 USD
Availability: InStock
Rating: 4.1 (10 reviews)

Fig. 1: Formalin-fixed, paraffin-embedded human GIST stained with DOG-1 Mouse Monoclonal Antibody (DG1/1486).

Anti-DOG-1 / TMEM16A (Gastrointestinal Stromal Tumor Marker) Monoclonal Antibody(Clone: DG1/1486)

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Fig. 1: Formalin-fixed, paraffin-embedded human GIST stained with DOG-1 Mouse Monoclonal Antibody (DG1/1486).

Fig. 2: SDS-PAGE Analysis Purified DOG-1 Mouse Monoclonal Antibody (DG1/1486). Confirmation of Purity and Integrity of Antibody.

Fig. 3: Analysis of Protein Array containing more than 19,000 full-length human proteins using DOG-1 Mouse Monoclonal Antibody (DG1/1486). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (Monoclonal Antibody) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a Monoclonal Antibody to its intended target. A Monoclonal Antibody is considered to specific to its intended target, if the Monoclonal Antibody has an S-score of at least 2.5. For example, if a Monoclonal Antibody binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that Monoclonal Antibody to protein X is equal to 29.

Product code: 36-2989

Clone name :	DG1/1486
Clonality :	Monoclonal
Application :	IHC
Reactivity :	Human

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Shipping Info:

For estimated delivery dates, please contact us at [email protected]

Download TDS MSDS

Amount :	100 µg
Isotype :	Mouse IgG2b, kappa
Content :	200 µg/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Storage condition :	Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous.


Gene :	TMEM16A
Gene ID :	55107
Uniprot ID :	Q5XX6
Alternative Name :	Anoctamin 1; Calcium Activated Chloride Channel; Discovered On Gastrointestinal Stromal Tumors Protein 1; TAOS2; ORAOV2; TMEM16A
Immunogen Information :	Recombinant human DOG-1 protein fragment (around aa 2-101) (exact sequence is proprietary)

Expression of DOG-1 protein is elevated in the gastrointestinal stromal tumors (GIST's), c-kit signaling-driven mesenchymal tumors of the GI tract. DOG-1 is rarely expressed in other soft tissue tumors, which, due to appearance, may be difficult to diagnose. Immunoreactivity for DOG-1 has been reported in 97.8 percent of scorable GIST's, including all c-kit negative GIST's. Overexpression of DOG-1 has been sÂµggested to aid in the identification of GISTs, including Platelet-Derived Growth Factor Receptor Alpha mutants that fail to express c-kit antigen. The overall sensitivity of DOG1 and c-kit in GIST's is nearly identical: 94.4% vs. 94.7%.

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes);

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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