Monoclonal Antibody to CD4 (Clone: RPA-T4)
CD4 is a 51 kDa membrane glycoprotein that is expressed on subsets of thymocytes and mature T lymphocytes where it works as co-receptor for T-cell receptor and interacts with MHC Class II processed antigens. CD4 is also expressed on surface of monocytes, macrophages and dendritic cells. CD4 also regulates T-cell activation and differention. CD4 is identified as the cellular receptor for HIV and several other viral infections. CD4 is highly expressed in thymus, spleen and lymphocyte.
|Purification :||Protein G Chromatography|
|Content :||25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.|
|Storage condition :||Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.|
FACS analysis: 0.5 µg/10^6 cells
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
|Subcellular location:||Cell membrane|
|Post transnational modification:||Phosphorylated by PKC; phosphorylation at Ser-433 plays an important role for CD4 internalization.|
|Tissue Specificity:||Highly expressed in T-helper cells. The presence of CD4 is a hallmark of T-helper cells which are specialized in the activation and growth of cytotoxic T-cells, regulation of B cells, or activation of phagocytes. CD4 is also present in other immune cells such as macrophages, dendritic cells or NK cells.|
|BioGrid:||107358. 94 interactions.|