Monoclonal Antibody to CD8 (Clone: RPAT8)
CD8 membrane glycoprotein that is expressed on cytotoxic T-cells where it interacts with MHC class I processed antigens. CD8 also regulates T-cell activation and differention. CD8 has two isoforms (25 and 21 kDa) CD8 can function either as a homodimer (two alpha chains) or as a heterodimer (one alpha and one beta chain). CD8 is highly expressed in T lymphocyte, peripheral blood T-lymphocytes, thymus, spleen and lymphocyte.
|Purification :||Protein G Chromatography|
|Content :||25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.|
|Storage condition :||Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.|
FACS analysis: 0.5 µg/10^6 cells
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
|Post transnational modification:||Phosphorylated in cytotoxic T-lymphocytes (CTLs) following activation.|
|Tissue Specificity:||CD8 on thymus-derived T-cells usually consists of a disulfide-linked alpha/CD8A and a beta/CD8B chain. Less frequently, CD8 can be expressed as a CD8A homodimer. A subset of natural killer cells, memory T-cells, intraepithelial lymphocytes, monocytes and dendritic cells expresses CD8A homo-dimers. Expressed at the cell surface of plasmacytoid dendritic cells upon herpes simplex virus-1 stimulation.|
|BioGrid:||107363. 14 interactions.|