Monoclonal Antibody to CK18 (Clone: DC10)
Keratins, also called cytokeratins, comprise a family of filamentous structural proteins that form the intermediate filaments of epithelial cells. Keratin proteins are differentially expressed depending on epithelial cell type and degree of differentiation. Antibody to a given keratin can be useful as a marker in of itself or as part of an antibody panel to help identify or classify tissue origin.
|Purification :||Protein G Chromatography|
|Content :||25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.|
|Storage condition :||Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.|
Western blot analysis: 1-3 µg/ml; Immunohistochemical analysis: 1:150-1:250
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
|Subcellular location:||Cytoplasm, Nucleus|
|Post transnational modification:||O-GlcNAcylation increases solubility, and decreases stability by inducing proteasomal degradation.|
|Tissue Specificity:||Expressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in lymph nodes of breast carcinoma.|
|BioGrid:||110073. 113 interactions.|