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  7. Monoclonal Antibody to DNMT3a (Clone: ABM1F35)

Monoclonal Antibody to DNMT3a (Clone: ABM1F35)

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Fig-1: Western blot analysis of DNMT3a. Anti-DNMT3a antibody (Clone: ABM1F35) was used at 2 µg/ml HEK 293 lysate

Monoclonal Antibody to DNMT3a (Clone: ABM1F35)

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Product code: 10-7004

Clone name : ABM1F35
Clonality : Monoclonal
Application : WB
Reactivity : Human

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Order now and get it on Tuesday January 26, 2021

Same day delivery FREE on San Diego area orders placed by 1.00 PM

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Same-day delivery in San Diego available for the following zip codes:

92121, 92122, 92037, 92117, 92109, 92110, 92101, 92010, 92011, 92009, 92008
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Available Pack Size(s)

  •   25 µg

  •  100 µg

  • $90.00 

  • $270.00 

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Shipping Info:

Order now and get it on Tuesday January 26, 2021

Same day delivery FREE on San Diego area orders placed by 1.00 PM

Download TDS MSDS

  • Product Info
  • Antigen Details
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Format : Purified
Amount : 100 µg
Isotype : Mouse IgG1 Kappa
Purification : Protein G Chromatography
Content : 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage condition : Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Gene : DNMT3A
Gene ID : 1788
Uniprot ID : Q9Y6K1
Alternative Name : DNMT3A
Immunogen Information : Full length recombinant DNMT3a protein was used as the immunogen for this antibody

Dnmt3a belongs to the mammalian methyltransferase gene family which is responsible for tissue-specific gene expression. Dnmt3a together with other methyltransferases conducts de novo methylation of cytosine residues in CpG islands by the enzymatic addition of methyl residues from S-adenosyl-L-methionine to the 5-carbon atom of the cytosine ring. Dnmt3a also directs a metabolic program by repressing key genes to enable the coupling of insulin secretion to glucose levels during beta cell maturation. Loss of Dnmt3a in pancreatic beta cells prevents this developmental metabolic reprogramming, resulting in loss of GSIS (Glucose-Stimulated Insulin Secretion)). Dnmt3a overexpression has been found in several cancers including AML (Acute Myeloid Leukemia).

Western blot analysis: 2-4 µg/ml

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Nucleus, Cytoplasm
Post transnational modification: Sumoylated; sumoylation disrupts the ability to interact with histone deacetylases (HDAC1 and HDAC2) and repress transcription.
Tissue Specificity: Highly expressed in fetal tissues, skeletal muscle, heart, peripheral blood mononuclear cells, kidney, and at lower levels in placenta, brain, liver, colon, spleen, small intestine and lung.
BioGrid: 108125. 53 interactions.
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Monoclonal Antibody to DNMT3a (Clone: ABM1F35)

Product code: 10-7004
*specify in mg or ml

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