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  7. Monoclonal Antibody to Human CD51/CD61 (Integrin alpha v beta 3) NALE™ Purified (Clone: 23C6)

Monoclonal Antibody to Human CD51/CD61 (Integrin alpha v beta 3) NALE™ Purified (Clone: 23C6)

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Monoclonal Antibody to Human CD51/CD61 (Integrin alpha v beta 3) NALE™ Purified (Clone: 23C6)

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Product code: 43-1001

Clone name : 23C6
Clonality : Monoclonal
Application : FACS
Reactivity : Human

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50 µg
$212.00 

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Amount : 50 µg
Isotype : Mouse IgG1, kappa
Purification : Purified (No Azide Low Endotoxin)
Content : 1 mg/ml in Phosphate-buffered aqueous solution, ph7.2.
Storage condition : The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
Gene : ITGB3
Gene ID : 3690
Uniprot ID : P05106
Alternative Name : Platelet membrane glycoprotein IIIa, GP3A

The 23C6 monoclonal antibody specifically reacts with the human CD51/61 molecule, known as the integrin alpha v Beta 3 complex or vitronectin receptor. The complex binds to other ligands such as CD29, fibrinogen, fibrinectin, vWf, laminin and thrombospondin. It is expressed by endothelial cells, osteoclasts, melanoma cells, and at low levels on platelets and macrophages. The 23C6 antibody is reported to be able to block the receptors ability to form interactions with some of its ligands.

The antibody has been analyzed for quality through the flow cytometric analysis of the relevant cell type. It is recommended that the reagent be titrated for optimal performance for each application.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Cell membrane, Cell projection, Cell junction
Post transnational modification: Phosphorylated on tyrosine residues in response to thrombin-induced platelet aggregation. Probably involved in outside-in signaling. A peptide (AA 740-762) is capable of binding GRB2 only when both Tyr-773 and Tyr-785 are phosphorylated. Phosphorylation of Thr-779 inhibits SHC binding.
Tissue Specificity: Isoform beta-3A and isoform beta-3C are widely expressed. Isoform beta-3A is specifically expressed in osteoblast cells; isoform beta-3C is specifically expressed in prostate and testis.
BioGrid: 109896. 41 interactions.
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Monoclonal Antibody to Human CD51/CD61 (Integrin alpha v beta 3) NALE™ Purified (Clone: 23C6)

Product code: 43-1001
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