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  7. Monoclonal Antibody to human DC-SIGN

Monoclonal Antibody to human DC-SIGN

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Monoclonal Antibody to human DC-SIGN

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Product code: 10-3552

Clone name : DCN47.5
Clonality : Monoclonal
Application : Functional Assay, FACS
Reactivity : Human

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  •   100 µg

  •  500 µg

  • $915.00 

  • $1,745.00 

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Amount : 500 µg
Isotype : Mouse IgG1
Content : 0.5 mg 0.2 µm filtered protein G purified antibody solution in PBS containing 0.1% bovine serum albumin.
Storage condition : Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.
Gene : CD209
Gene ID : 30835
Uniprot ID : Q9NNX6
Alternative Name : CLEC4L, C-type lectin domain family 4 member L, Dendritic cell-specific ICAM-3-grabbing non-integrin 1
Immunogen Information : Human monocyte-derived dendritic cells

The monoclonal antibody DCN47.5 reacts with the C-type lectin, DC-SIGN (CD209), exclusively expressed on human dendritic cells (DC). DC are specialized antigen presenting cells and bridge the innate and the adaptive immune system. They provide high levels of costimulation necessary for activation of both naïve and antigen-experienced T-cells. Immature DC are capable to migrate to inflammatory sites, capture antigen and process it internally to form MHC-peptide complexes. Following antigen uptake, DC undergo maturation and migrate to lymphoid organs where they can present MHC-peptide complexes to resting T-cells and drive T-cell proliferation. During differentiation and maturation of DC, several phenotypic surface markers are expressed: CD1a, CD4, CD11, CD40, CD86, and HLA-DR. Immature DC predominantly express CCR5 which enables DC to migrate to inflammatory sites, whereas mature DC express high levels of CXCR4, a receptor that facilitates migration to lymphoid organs. DC also express DC-specific, ICAM-3 grabbing, nonintegrin (DC-SIGN), a 44 kDa C-type lectin that binds to the HIV-1 envelope glycoprotein gp120, ICAM-3 on T-cells and ICAM-2 on endothelial cells. HIV virions are able to infect cells expressing CD4 and the chemokine co-receptors CCR5 or CXCR4 and can attach to DC-SIGN to extend virion lifespan. Therefore, DC are candidates for HIV-1 infection. DC-SIGN-ICAM-3 binding is integrin-independent but calcium-dependent and antibodies reactive against DC-SIGN can be used to study DC-SIGN-ICAM3 binding. The monoclonal antibody DCN47.5 specifically reacts with the C-type lectin DC-SIGN (CD209) expressed on human dendritic cells and inhibits binding of DC-SIGN to ICAM-2 on endothelial cells.

Dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Secreted
Tissue Specificity: Predominantly expressed in dendritic cells and in DC-residing tissues. Also found in placental macrophages, endothelial cells of placental vascular channels, peripheral blood mononuclear cells, and THP-1 monocytes.
BioGrid: 119051. 14 interactions.
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Monoclonal Antibody to human DC-SIGN

Product code: 10-3552
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