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    7. Monoclonal Antibody to p53 (Clone BP53-12)

    Monoclonal Antibody to p53 (Clone BP53-12)

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    Fig: 1 Western blot analysis of p53. Anti p53 antibody (Clone: BP53-12) was used at 1 µg/ml on 1) A431, 2) MCF7, 3) HEK293 lysates.

    Monoclonal Antibody to p53 (Clone BP53-12)
    Monoclonal Antibody to p53 (Clone BP53-12)

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    Fig: 1 Western blot analysis of p53. Anti p53 antibody (Clone: BP53-12) was used at 1 µg/ml on 1) A431, 2) MCF7, 3) HEK293 lysates.
    Fig: 2 Immunohistochemical analysis of p53 in human colon carcinoma using p53 antibody (Clone: BP53-12) at 1:100 dilution.

    Product code: 10-1053

    Clone name : BP53-12
    Clonality : Monoclonal
    Application : IHC, WB
    Reactivity : Human

    Shipping Info:

    Order now and get it on Tuesday July 05, 2022

    Same day delivery FREE on San Diego area orders placed by 1.00 PM

    Local delivery areas

    Same-day delivery in San Diego available for the following zip codes:

    92121, 92122, 92037, 92117, 92109, 92110, 92101, 92010, 92011, 92009, 92008
    Download TDS MSDS
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    Size
    Price
    100 µg
    $260.00 

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    Shipping Info:

    Order now and get it on Tuesday July 05, 2022

    Same day delivery FREE on San Diego area orders placed by 1.00 PM

    Download TDS MSDS

    • Product Info
    • Antigen Details
    • Description
    • Application Note
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    • Review   (0)
    Format : Purified
    Amount : 100 µg
    Isotype : Mouse IgG2a Kappa
    Purification : Protein G Chromatography
    Content : 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
    Storage condition : Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.
    Gene : TP53
    Gene ID : 7157
    Uniprot ID : P04637
    Alternative Name : TP53, P53
    Immunogen Information : Recombinant human wild-type p53 protein was used as immunogen.

    Recognizes a 53kDa protein, which is identified as p53 suppressor gene product. It reacts with the mutant as well as the wild form of p53 under denaturing and non-denaturing conditions. p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to MDM2, SV40 T antigen and human papilloma virus E6 protein. Positive nuclear staining with p53 antibody has been reported to be a negative prognostic factor in breast carcinoma, lung carcinoma, colorectal, and urothelial carcinoma. Anti-p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia. Mutations involving p53 are found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma.

    Western blot analysis: 1-2 µg/ml; Immunohistochemical analysis: 1:100-1:200

    For Research Use Only. Not for use in diagnostic/therapeutics procedures.

    Subcellular location: Cytoplasm
    Post transnational modification: Sumoylated with SUMO1. Sumoylated at Lys-386 by UBC9.
    Tissue Specificity: Ubiquitous. Isoforms are expressed in a wide range of normal tissues but in a tissue-dependent manner. Isoform 2 is expressed in most normal tissues but is not detected in brain, lung, prostate, muscle, fetal brain, spinal cord and fetal liver. Isoform 3 is expressed in most normal tissues but is not detected in lung, spleen, testis, fetal brain, spinal cord and fetal liver. Isoform 7 is expressed in most normal tissues but is not detected in prostate, uterus, skeletal muscle and breast. Isoform 8 is detected only in colon, bone marrow, testis, fetal brain and intestine. Isoform 9 is expressed in most normal tissues but is not detected in brain, heart, lung, fetal liver, salivary gland, breast or intestine.
    BioGrid: 113010. 1093 interactions.
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    Monoclonal Antibody to p53 (Clone BP53-12)

    Product code: 10-1053
    *specify in mg or ml

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