Mouse Monoclonal Antibody to Human RANTES (Clone : 4A10F2)(Discontinued)
|Amount :||40 µg|
|Isotype :||Mouse IgG2b,κ|
|Purification :||Protein A chromatography|
|Content :||0.5 mg/ml, lyophilized with PBS, pH 7.4, containing 0.02% sodium azide|
|Storage condition :||The antibody is stable in lyophilized form if stored at -20°C or below. The reconstituted antibody can be stored for 2-3 weeks at 2-8°C. For long term storage, aliquot and store at -20°C or below. Avoid repeated freezing and thawing cycles.|
RANTES is a chemoattractant for blood monocytes, memory T helper cells, and eosinophils. It causes the release of histamine from basophils and activates eosinophils and binds to CCR1, CCR3, CCR4, and CCR5. It is also one of the major HIV suppressive factors produced by CD8+ T cells. Recombinant RANTES protein induces a dose dependent inhibition of different strains of HIV HIV 2, and simian immunodeficiency virus (SIV). Induced by mitogens, it is T cell and macrophage specific and belongs to the intercrine beta (chemokine CC) family. Human RANTES Antibody (4A10F2), mAb, Mouse is produced from the hybridoma resulting from fusion of Sp2/0 myeloma and lymphocytes obtained from mouse immunized with purified full length human recombinant RANTES protein (Swiss Prot: P13501).
Western blot: 1-2 µg/ml.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.