Mouse Monoclonal Antibody to IL-8 (Clone : 3B1C10)(Discontinued)
Figure-1 : Western blot analysis of IL-8 Antibody (Clone: 3B1C10) at 1 μg/ml on purified recombinant IL-8 (100ng, 50ng & 20 ng ).
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| Format : | Purified |
| Amount : | 500 µg |
| Isotype : | Mouse IgG1 |
| Purification : | Protein G chromatography |
| Content : | 100 µg, 1 mg/ml in PBS, pH 7.4 with 0.02% sodium azide and 500 µg, 0.5 mg/ml, lyophilized with PBS, pH 7.4, containing 0.02% sodium azide. Reconstitute the lyophilized powder with deionized water to an antibody concentration of 0.5 mg/ml. |
| Storage condition : | The antibody is stable in lyophilized form if stored at -20°C or below. The reconstituted antibody can be stored for 2-3 weeks at 2-8°C. For long term storage, aliquot and store at -20°C or below. Avoid repeated freezing and thawing cycles. |
| Gene : | CXCL8 |
| Gene ID : | 3576 |
| Uniprot ID : | P10145 |
| Alternative Name : | IL-8, Interleukin-8, Interleukin-8, Neutrophil activating protein-1, C-X-C motif chemokine 8, Chemokine (C-X-C motif) ligand 8, Emoctakin, Granulocyte chemotactic protein 1, Monocyte-derived neutrophil chemotactic factor, Protein 3-10C, T-cell chemotactic factor |
| Immunogen Information : | Purified recombinant human IL-8 |
IL-8, also known as neutrophil chemotactic factor, neutrophil activating protein, and monocyte-derived neutrophil chemotactic factor, is a member of the alpha (C-X-C) subfamily of chemokines called CXCL8. In response to proinflammatory stimuli, IL-8 is produced by monocytes, macrophages, T cells, neutrophils, and fibroblasts. IL-8 promotes neutrophil chemotaxis and degranulation. The 72-amino acid IL-8 is the predominant form secreted by monocytes and lymphocytes. Recombinant human IL-8 is an 8,400 Da protein containing 72 amino acids. This antibody reacts with human Interleukin-8 (IL-8) protein. The immunogen used to produce the antibody is recombinant human IL-8 produced in E. coli containing 72 amino acids and having a molecular mass of 8,452 Da.
ELISA: 0.1-1 µg/ml
Western blot: 1-2 µg/ml
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Secreted |
| Post transnational modification: | Citrullination at Arg-27 prevents proteolysis, and dampens tissue inflammation, it also enhances leukocytosis, possibly through impaired chemokine clearance from the blood circulation. |
| BioGrid: | 109790. 12 interactions. |
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