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    7. Mouse Monoclonal Antibody to p53 (Clone : 2D2G6)(Discontinued)

    Mouse Monoclonal Antibody to p53 (Clone : 2D2G6)(Discontinued)

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    Figure-1 : Western blot analysis of p53 Antibody (Clone: 2D2G6) at 1 µg/ml on human recombinant p53 isoforms (Delta 40p53, Delta 40p53 beta, Delta 40p53 gamma, Delta 133p53, Delta133p53 beta, Delta 133p53 gamma, p53 beta, p53 gamma).

    Mouse Monoclonal Antibody to p53 (Clone : 2D2G6)(Discontinued)
    Mouse Monoclonal Antibody to p53 (Clone : 2D2G6)(Discontinued)
    Mouse Monoclonal Antibody to p53 (Clone : 2D2G6)(Discontinued)

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    Figure-1 : Western blot analysis of p53 Antibody (Clone: 2D2G6) at 1 µg/ml on human recombinant p53 isoforms (Delta 40p53, Delta 40p53 beta, Delta 40p53 gamma, Delta 133p53, Delta133p53 beta, Delta 133p53 gamma, p53 beta, p53 gamma).
    Figure-2 : Western blot analysis of p53 Antibody (Clone: 2D2G6) at 1 µg/ml on UV-treated HEK 293 cell lysates, IRDye 800 Conjugated Goat Anti-mouse IgG was used as secondry Antibody.
    Figure-3 : Flow cytometric analysis of p53 Antibody (Clone:2D2G6) on HEK293 cells at 2 µg for 1 x 10^6 cells, Red histogram represents p53 Antibody (Clone:2D2G6) and green histogram represents isotype control.

    Product code: 45-1062

    Clone name : 2D2G6
    Clonality : Monoclonal
    Application : ELISA
    Reactivity : Human

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    Shipping Info:

    For estimated delivery dates, please contact us at support@abeomics.com

    Download TDS MSDS

    • Product Info
    • Antigen Details
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    Format : Purified
    Amount : 40 µg
    Isotype : Mouse IgG1
    Purification : Protein A chromatography
    Content : 0.5 mg/ml, lyophilized with PBS, pH 7.4, containing 0.02% sodium azide.
    Storage condition : The antibody is stable in lyophilized form if stored at -20°C or below. The reconstituted antibody can be stored for 2-3 weeks at 2-8°C. For long term storage, aliquot and store at -20°C or below. Avoid repeated freezing and thawing cycles.
    Gene : TP53
    Gene ID : 7157
    Uniprot ID : P04637
    Alternative Name : Cellular tumor antigen p53, Antigen NY-CO-13, Phosphoprotein p53, Tumor suppressor p53
    Immunogen Information : Human recombinant wild type p53

    The p53 tumor suppressor protein plays a major role in cellular response to DNA damage and other genomic aberrations. It is situated at the crossroads of signalling pathways that are essential for cell growth regulation and apoptosis. In normal unstressed cells, the level of p53 protein is downregulated via the binding of proteins such as MDM2, COP1, PIRH2 or JNK that promote p53 degradation via the ubiquitin/proteasome pathway. As most of these genes are up regulated by p53, this lead to a regulation loop that will keep p53 level very low in a normal cells. Alternative splicing of the human p53 gene gives rise of p53 beta, p53 gamma, Delta 40p53 (also known as p44, p47 or delat N p53), Delta 40p53 beta, Delta 40 p53gamma, Delta 133p53, Delta 133p53 beta, and Delta 133p53 gamma. p53 Antibody (2D2G6), mAb, Mouse is produced from the hybridoma resulting from fusion of SP2/0-Ag14 myeloma and B-lymphocytes obtained from mouse immunized with human recombinant wild type p53 (wt p53).

    ELISA: 0.05-0.1 µg/ml
    Western blot: 1-2 µg/ml
    Flow cytometry: 2 µg for 1 x 106 cells

    For Research Use Only. Not for use in diagnostic/therapeutics procedures.

    Subcellular location: Cytoplasm
    Post transnational modification: Sumoylated with SUMO1. Sumoylated at Lys-386 by UBC9.
    Tissue Specificity: Ubiquitous. Isoforms are expressed in a wide range of normal tissues but in a tissue-dependent manner. Isoform 2 is expressed in most normal tissues but is not detected in brain, lung, prostate, muscle, fetal brain, spinal cord and fetal liver. Isoform 3 is expressed in most normal tissues but is not detected in lung, spleen, testis, fetal brain, spinal cord and fetal liver. Isoform 7 is expressed in most normal tissues but is not detected in prostate, uterus, skeletal muscle and breast. Isoform 8 is detected only in colon, bone marrow, testis, fetal brain and intestine. Isoform 9 is expressed in most normal tissues but is not detected in brain, heart, lung, fetal liver, salivary gland, breast or intestine.
    BioGrid: 113010. 1093 interactions.
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    Mouse Monoclonal Antibody to p53 (Clone : 2D2G6)(Discontinued)

    Product code: 45-1062
    *specify in mg or ml

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