PE Conjugated Anti-LARGE1 Monoclonal Antibody (Clone:LARGE-02)
Figure 1: Flow cytometry analysis of LARGE1 in HEK293-LARGE1 transfectants using mouse monoclonal antibody (clone LARGE-02) PE.
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| Amount : | 0.1 mg |
| Isotype : | Mouse IgG2b |
| Storage condition : | Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. |
LARGE1 serves as a glycosyltransferase which participates in glycosylation of the muscle membrane protein alpha-dystroglycan. Mutations of LARGE1 lead to hypoglycosylation of alpha-dystroglycan and cause congenital muscular dystrophy (MDC1D) associated with severe mental retardation. Altered alpha-dystroglycan glycosylation may also play a role in cancer, as hypoglycosylation of the protein and loss of laminin binding have been demonstrated in invasive carcinoma cells.
| Subcellular location: | Golgi apparatus membrane |
| Tissue Specificity: | Ubiquitous. Highest expression in heart, brain and skeletal muscle. |
| BioGrid: | 114649. 11 interactions. |
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.png "ACE2/HEK293 Stable Cell Line")
