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    7. Phospho-CrkL (Tyr207) (Clone: G4) rabbit mAb

    Phospho-CrkL (Tyr207) (Clone: G4) rabbit mAb

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    Fig-1: Flow cytometric analysis of K562 cells secondary antibody only negative control (blue) or imatinib (red) or treated with pervanadate (green) using Phospho-CrkL (Tyr207) antibody CrkLY207-G4 at 0.05 µg/mL.

    Phospho-CrkL (Tyr207) (Clone: G4) rabbit mAb
    Phospho-CrkL (Tyr207) (Clone: G4) rabbit mAb
    Phospho-CrkL (Tyr207) (Clone: G4) rabbit mAb
    Phospho-CrkL (Tyr207) (Clone: G4) rabbit mAb
    Phospho-CrkL (Tyr207) (Clone: G4) rabbit mAb
    Phospho-CrkL (Tyr207) (Clone: G4) rabbit mAb

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    Fig-1: Flow cytometric analysis of K562 cells secondary antibody only negative control (blue) or imatinib (red) or treated with pervanadate (green) using Phospho-CrkL (Tyr207) antibody CrkLY207-G4 at 0.05 µg/mL.
    Fig 2 : Western blot analysis of K562 cell extract untreated or treated with imatinib using 1ng/mL CrkL (Tyr207) antibody CrkLY207-G4.
    Fig-3: Peptide blocking flow cytometric analysis of K562 cells secondary antibody only negative control (light blue) or treated with imatinib (red) or treated with pervanadate (green) or imatinib and blocked with phospho-peptide (black) or pervanadate and blocked with phospho peptide (gold) or imatinib and blocked with non-phospho peptide (dark blue) or pervanadate and blocked with non-phospho peptide (purple) using Phospho-CrkL (Tyr207) antibody CrkLY207-G4 at 0.01µg/mL.
    Fig-4: Western blot analysis of NIH3T3 cell extract using 1µg/mL Phospho-CrkL (Tyr207) antibody CrkLY207-G4.
    Fig-5: Western blot of E10.5 mouse wild-type (+/+) or Crkl knock out (-/-) whole embryos. The red channel was stained using a B-actin loading control and the green channel was stained using 1:500 dilution of Phospho-CrkL (Tyr207) antibody CrkLY207-G4. Phospho CrkL antibody staining is absent in the knock out lysate.
    Fig-6: Flow cytometric analysis of K562 cells secondary antibody only negative control (blue) or treated with imatinib (red) or with pervanadate (green) using 0.05 µg/mL of Phospho-CrkL (Tyr207) antibody CrkLY207-G4 or Company C antibody at 0.1µg/mL.

    Product code: 12-4073

    Clone name : CrkLY207-G4
    Clonality : Monoclonal
    Application : FACS, WB
    Reactivity : Human, Mouse
    Conjugate : Unconjugated

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    For estimated delivery dates, please contact us at support@abeomics.com

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    •   20 µl

    •  200 µl

    • $278.00 

    • $540.00 

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    For estimated delivery dates, please contact us at support@abeomics.com

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    • Product Info
    • Antigen Details
    • Description
    • Application Note
    • Review   (0)
    Format : Purified
    Amount : 200 µl
    Isotype : Rabbit IgG1k
    Content : 1X PBS, 0.02% NaN3, 50% Glycerol, 0.1% BSA
    Storage condition : Store at -20°C. Avoid repeated freeze and thaw cycles.
    Alternative Name : Crk-like protein; CRKL; v-crk sarcoma virus CT10 oncogene homolog (avian)-like
    Immunogen Information : A synthetic phospho-peptide corresponding to residues surrounding Tyr207 of human phospho CrkL
    CrkL (v-Crk sarcoma virus CT10 oncogene-like protein) is an adaptor protein composed of one Src Homology 2 (SH2) and two Src Homology 3 (SH3) domains separated by flexible linker sequences that act as building blocks to assemble multiprotein complexes (1). The Crk adaptor proteins (Crk and CrkL) constitute an integral part of a network of essential signal transduction pathways in humans and other organisms that act as major convergence points in tyrosine kinase signaling. CRKL is required for the normal development of multiple tissues that rely on fibroblast growth factor 8 (FGF8). Phosphorylation of Crk on Tyr 221 or CrkL on Tyr 207 causes intramolecular binding of the linker region to the SH2 domain, sequestering the SH2 and SH3N and preventing them from binding target proteins (2,3). Mounting evidence indicates that dysregulation of Crk proteins is associated with human diseases, including cancer and susceptibility to pathogen infections.

    1µg/mL - 0.001µg/mL. It is recommended that the reagent be titrated for optimal performance for each application. See product image legends for additional information.(0.5mg/ml, more than 200 western blots)

    For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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    Phospho-CrkL (Tyr207) (Clone: G4) rabbit mAb

    Product code: 12-4073
    *specify in mg or ml

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