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  7. Polyclonal Antibody to alpha-Tubulin

Polyclonal Antibody to alpha-Tubulin

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Figure 1: Western blot analysis of extracts from Hela and HT29 cells using alpha-Tubulin Antibody 35-1765 .

Polyclonal Antibody to alpha-Tubulin

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Product code: 35-1765

Clonality : Polyclonal
Application : WB
Reactivity : Rat, Mouse, Human

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  •   50 µl

  •  100 µl

  • $349.00 

  • $412.00 

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Format : Purified
Amount : 100 µl
Isotype : Rabbit IgG
Content : Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage condition : Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Gene : TUBA4A
Gene ID : 7277
Uniprot ID : P68366
Alternative Name : Alpha-tubulin 1, Testis-specific alpha-tubulin, Tubulin H2-alpha, Tubulin alpha-1 chain
Immunogen Information : Peptide sequence around aa.437-441(V-D-S-V-E) derived from Human alpha-Tubulin.

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the a-chain.

Predicted MW: 52kd, Western blotting: 1:500~1:1000

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Cytoplasm
Post transnational modification: Detyrosinated tubulin alpha-1B chain: Detyrosination is involved in metaphase plate congression by guiding chromosomes during mitosis: detyrosination promotes interaction with CENPE, promoting pole-proximal transport of chromosomes toward the equator (PubMed:25908662). Detyrosination increases microtubules-dependent mechanotransduction in dystrophic cardiac and skeletal muscle. In cardiomyocytes, detyrosinated microtubules are required to resist to contractile compression during contraction: detyrosination promotes association with desmin (DES) at force-generating sarcomeres, leading to buckled microtubules and mechanical resistance to contraction (By similarity).
BioGrid: 115651. 161 interactions.
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Polyclonal Antibody to alpha-Tubulin

Product code: 35-1765
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