Rabbit Polyclonal Antibody to BRCA2(Discontinued)
|Amount :||40 µg|
|Isotype :||Rabbit IgG|
|Purification :||Immunoaffinity chromatography.|
|Content :||0.5 mg/ml, lyophilized with PBS, pH 7.4, containing 0.02% sodium azide.|
|Storage condition :||The antibody is stable in lyophilized form if stored at -20°C or below. The reconstituted antibody can be stored for 2-3 weeks at 2-8°C. For long term storage, aliquot and store at -20°C or below. Avoid repeated freezing and thawing cycles.|
Breast cancer type 2 susceptibility protein (BRCA2) is involved in double-strand break repair and/or homologous recombination. It may participate in S phase checkpoint activation. In addition, It interacts with RAD51 and DSS1 and binds to ubiquitinated FANCD2. It also interacts with PALB2, enabling the recombinational repair and checkpoints functions. Defects in BRCA2 can cause genetic susceptibility to breast cancer (BC), also called susceptibility to familial breast-ovarian cancer type 2 (BROVCA2). BRCA2 Antibody is developed in rabbit using a KLH-coupled synthetic peptide within residues 24802530 of human BRCA2 (Swiss Prot: P51587).
Flow cytometry: 2 µg for 1 x 106 cells
For Research Use Only. Not for use in diagnostic/therapeutics procedures.