Recombinant 2019-nCoV S1 Protein (Mammalian, D614G,C-10His)
|Amount :||50 µg|
|Content :||Supplied as a 0.2 µM filtered solution of PBS, pH 7.4.|
|AA sequence :||Recombinant 2019-nCoV S1 Protein is produced by our Mammalian expression system and the target gene encoding Gln14-Arg685(D614G) is expressed with a 10His tag at the C-terminus.|
|Alternative Name :||S1 protein; 2019-nCoV S1 protein; coronavirus S1 Protein; cov S1 Protein|
The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.