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    5. Recombinant Cynomolgus Colony CD3E (C-Fc)

    Recombinant Cynomolgus Colony CD3E (C-Fc)

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    Recombinant Cynomolgus Colony CD3E (C-Fc)

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    Product code: 32-9634

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    •   500 µg

    •  50 µg

    • $1,535.00 

    • $464.00  $394.40 

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    Amount : 50 µg
    Content : Lyophilized from a 0.2 µm filtered solution of 50 mM Tris, 100 mM Glycine, pH7.5.
    AA sequence : Recombinant Cynomolgus monkey T-cell Surface Glycoprotein CD3 Epsilon Chain is produced by our Mammalian expression system and the target gene encoding Gln22-Asp117 is expressed with a Fc tag at the C-terminus.
    Alternative Name : CD3 epsilon; CD3e antigen; CD3e antigen, epsilon polypeptide (TiT3 complex); CD3e molecule, epsilon (CD3-TCR complex); CD3e; CD3-epsilon; FLJ18683; T3E; T-cell antigen receptor complex, epsilon subunit of T3; T-cell surface antigen T3/Leu-4 epsilon chain; T-cell surface glycoprotein CD3 epsilon chain; TCRE
    Source : Human Cells;
    T-cell surface glycoprotein CD3 epsilon chain, also known as CD3E, is a single-pass type I membrane protein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. The CD3 epsilon subunit of the T cell receptor (TCR) complex contains two defined signaling domains, a proline-rich sequence and an immune tyrosine activation motifs (ITAMs), and this complex undergoes a conformational change upon ligand binding that is thought to be important for the activation of T cells. T cell receptor-CD3 complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. This complex is critical for T-cell development and function, and represents one of the most complex transmembrane receptors. CD3E plays an essential role in T-cell development, and defects in CD3E gene cause severe immunodeficiency. Homozygous mutations in CD3D and CD3E genes lead to a complete block in T-cell development and thus to an early-onset severe combined immunodeficiency phenotype.
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    Recombinant Cynomolgus Colony CD3E (C-Fc)

    Product code: 32-9634
    *specify in mg or ml

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