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Fig-1: Cell surface flow analysis of Rabbit recombinant hPD-1 antibody in PHA treated PBMC (Lymphocyte gated) using 0.5 µg/10^6 cells of Rabbit recombinant hPD-1 antibody (Clone:ABMRR01). Green represent isotype control and red represent Rabbit recombinant hPD-1 antibody. Goat anti rabbit FITC conjugate was used as secondary antibody.
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PDCD-1 (programmed cell death-1 protein), also designated CD279, is a type I transmembrane receptor and a member of the immunoglobin gene superfamily. It is expressed on activated T-cells, B-cells, and myeloid cells. Anti-PDCD-1 is a marker of angioimmunoblastic lymphoma and suggests a unique cell of origin for this neoplasm. Unlike CD10 and BCL6, PDCD-1 is expressed by few B-cells, so anti-PDCD-1 may be a more specific and useful diagnostic marker in angioimmunoblastic lymphoma. In addition, PDCD-1 expression provides evidence that angioimmunoblastic lymphoma is a neoplasm derived from germinal center-associated T-cells.
FACS: 0.5-1 µg/10^6, WB: 1-2 µg/ml
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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