Recombinant Human Interleukin-10 Receptor Subunit Alpha/IL-10 Ra (C-6His)
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|Amount :||50 ug|
|Content :||0.2 mg /ml in Sterile filted solution of PBS, pH7.4.|
|Storage condition :||Aliquoted proteins are stable at -20°C for 3 months.|
|AA sequence :||HGTELPSPPSVWFEAEFFHHILHWTPIPNQSESTCYEVALLRYGIESWNSISNCSQTLSYDLTAVTLDLYHSNGYRARVRAVDGSRHSNWTVTNTRFSVDEVTLTVGSVNLEIHNGFILGKIQLPRPKMAPANDTYESIFSHFREYEIAIRKVPGNFTFTHKKVKHENFSLLTSGEVGEFCVQVKPSVASRSNKGMWSKEECISLTRQYFTVTNHHHHHH|
Source: E. coli.
Recombinant Human Interleukin-10 Receptor Subunit Alpha is produced by our E. coli expression system and the target gene encoding His22-Asn235 is expressed with a 6His tag at the C-terminus. Interleukin-10 Receptor alpha (IL-10Ra) is a transmembrane glycoprotein member of the class II cytokine receptor family. Mature human IL-10 Ra consists of a 214 amino acid (aa) extracellular domain (ECD), a 21 aa transmembrane segment, and a 322 aa cytoplasmic domain. Within the ECD, human IL-10 Ra shares 59% aa sequence identity with mouse and rat IL-10Ra. IL-10 Ra is required for mediating the effects of IL-10,a critical molecule in the control of microbial infections, allergic and autoimmune inflammation, and cancer. IL-10Ra is the ligand specific subunit of the IL-10 receptor complex. Noncovalent dimers of IL-10 bind to IL-10 Ra, resulting in the recruitment of IL-10 R beta. Immunosuppressive signal transduction through the IL-10 receptor complex can be inhibited by activation of TLR2, 4, or 9, enabling strengthened immune responses during infection. Polymorphisms of human IL-10 Ra may limit viral immune evasion by retaining full responsiveness to human IL-10 but responding weakly to the cytomegalovirus homolog of IL10.
Endotoxin : Less than 0.1 ng/µg (1 IEU/µg) as determined by LAL test.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
|Subcellular location:||Cell membrane, Cytoplasm|
|Post transnational modification:||Ubiquitinated by BTRC; ubiquitination leads to endocytosis and subsequent degradation of IL10RA.|
|Tissue Specificity:||Primarily expressed in hematopoetic cells including B-cells, T-cells, NK cells, monocytes and macrophages. Not expresssed in non-hematopoetic cells such as fibroblasts or endothelial cells.|
|BioGrid:||109801. 4 interactions.|
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