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    5. Recombinant Human Interleukin-10 Receptor Subunit Alpha/IL-10 Ra (C-6His)

    Recombinant Human Interleukin-10 Receptor Subunit Alpha/IL-10 Ra (C-6His)

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    Recombinant Human Interleukin-10 Receptor Subunit Alpha/IL-10 Ra (C-6His)

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    Product code: 32-8845

    Shipping Info:

    Order now and get it on Tuesday May 24, 2022

    Same day delivery FREE on San Diego area orders placed by 1.00 PM

    Local delivery areas

    Same-day delivery in San Diego available for the following zip codes:

    92121, 92122, 92037, 92117, 92109, 92110, 92101, 92010, 92011, 92009, 92008
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    Size
    Price

    Available Pack Size(s)

    •   10 µg

    •  50 ug

    • $319.00 

    • $573.00  $458.40 

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    Shipping Info:

    Order now and get it on Tuesday May 24, 2022

    Same day delivery FREE on San Diego area orders placed by 1.00 PM

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    • Review   (0)
    Amount : 50 ug
    Content : 0.2 mg /ml in Sterile filted solution of PBS, pH7.4.
    Storage condition : Aliquoted proteins are stable at -20°C for 3 months.
    AA sequence : HGTELPSPPSVWFEAEFFHHILHWTPIPNQSESTCYEVALLRYGIESWNSISNCSQTLSYDLTAVTLDLYHSNGYRARVRAVDGSRHSNWTVTNTRFSVDEVTLTVGSVNLEIHNGFILGKIQLPRPKMAPANDTYESIFSHFREYEIAIRKVPGNFTFTHKKVKHENFSLLTSGEVGEFCVQVKPSVASRSNKGMWSKEECISLTRQYFTVTNHHHHHH
    Gene : IL10RA
    Gene ID : 3587
    Uniprot ID : Q13651

    Source: E. coli.
    MW :25.2kD.
    Recombinant Human Interleukin-10 Receptor Subunit Alpha is produced by our E. coli expression system and the target gene encoding His22-Asn235 is expressed with a 6His tag at the C-terminus. Interleukin-10 Receptor alpha (IL-10Ra) is a transmembrane glycoprotein member of the class II cytokine receptor family. Mature human IL-10 Ra consists of a 214 amino acid (aa) extracellular domain (ECD), a 21 aa transmembrane segment, and a 322 aa cytoplasmic domain. Within the ECD, human IL-10 Ra shares 59% aa sequence identity with mouse and rat IL-10Ra. IL-10 Ra is required for mediating the effects of IL-10,a critical molecule in the control of microbial infections, allergic and autoimmune inflammation, and cancer. IL-10Ra is the ligand specific subunit of the IL-10 receptor complex. Noncovalent dimers of IL-10 bind to IL-10 Ra, resulting in the recruitment of IL-10 R beta. Immunosuppressive signal transduction through the IL-10 receptor complex can be inhibited by activation of TLR2, 4, or 9, enabling strengthened immune responses during infection. Polymorphisms of human IL-10 Ra may limit viral immune evasion by retaining full responsiveness to human IL-10 but responding weakly to the cytomegalovirus homolog of IL10.

    Endotoxin : Less than 0.1 ng/µg (1 IEU/µg) as determined by LAL test.

    For Research Use Only. Not for use in diagnostic/therapeutics procedures.

    Subcellular location: Cell membrane, Cytoplasm
    Post transnational modification: Ubiquitinated by BTRC; ubiquitination leads to endocytosis and subsequent degradation of IL10RA.
    Tissue Specificity: Primarily expressed in hematopoetic cells including B-cells, T-cells, NK cells, monocytes and macrophages. Not expresssed in non-hematopoetic cells such as fibroblasts or endothelial cells.
    BioGrid: 109801. 4 interactions.
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    Recombinant Human Interleukin-10 Receptor Subunit Alpha/IL-10 Ra (C-6His)

    Product code: 32-8845
    *specify in mg or ml

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