Recombinant human PD-1 protein with C-terminal mouse Fc and 6×His tag
|The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
|Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
|Storage condition :
|Store at -80°C for 12 months (Avoid repeated freezing and thawing)
|Alternative Name :
|PDCD1, PD1, CD279, SLEB2
The protein has a predicted molecular mass of 43.5 kDa after removal of the signal peptide.
This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases.