5-HT2C Stable Cell Line-HEK293-Human
Figure 1: Functional analysis of 5-HT2C receptor.
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| Amount : | 2 vials |
| Content : | Each Vial contains cells in 45% culture medium, 45% FBS, 10% DMSO |
| Storage condition : | Immediately upon receipt, store in liquid nitrogen. |
| Alternative Name : | Human Recombinant 5-HT2C Serotonin Receptor Stable Cell Line |
5-Hydroxytryptamine (5-HT, also commonly known as serotonin) is synthesized in enterochromaffin cells in the intestine and in serotonergic nerve terminals. In the periphery, 5-HT mediates gastrointestinal motility, platelet aggregation, and contraction of blood vessels. Many functions of the central nervous system are influenced by 5-HT, including sleep, motor activity, sensory perception, arousal, and appetite. A family of 12 GPCRs and one ion channel mediate the biological effects of 5-HT (Hoyer et al., 1994). 5HT2C is expressed in the brain and spinal cord, especially the choroid plexus. 5HT2C receptor agonists may have important clinical value in the treatment of mental and eating disorders, such as depression, panic anxiety, OCD, bulimia, and obesity. The cloned human 5-HT2C expressing cell line is generated in the CHO-K1 host.
Application: Screen for antibodies through Flow Cytometry, Immunocytochemistry or Western blotting and analyzing receptors.
Culture Medium: DMEM, 10% FBS, 300 mg/ml G418
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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