Anti-4-1BB Ligand antibody(DM68), Rabbit mAb
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|Amount :||100 µg|
|Isotype :||Rabbit IgG|
|Purification :||Purified from cell culture supernatant by affinity chromatography|
|Content :||Preservative: 0.1% Procline 300
Constituents: 50% Glycerol; PBS,pH 7.4; 0.1% BSA
|Storage condition :||Store at -20°C for 12 months (Avoid repeated freezing and thawing)|
|Alternative Name :||4-1BB Ligand,TNFSF9,CD137L|
|Immunogen Information :||Recombinant human 4-1BB Ligand (Pro52-Glu254) produced by using human HEK293 cells|
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.
Recommended Dilutions ELISA 1/5000-10000;FACS 1/100
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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