Anti-ACE2 Rab mAb (Clone: SN0754)
|Isotype :||Rabbit IgG|
|Purification :||Protein A affinity purified|
|Content :||TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.|
|Storage condition :||Store at -20°C.|
|Uniprot ID :||Q9BYF1|
|Immunogen Information :||Recombinant Protein|
Calculated MW 92 kDa;
Angiotensin-converting enzyme (ACE) is a carboxyl-terminal dipeptidyl exopeptidase that converts angiotensin I to the potent vasopressive hormone, angiotensin II. There are two isoforms of ACE, the pulmonary ACEP and the testicular ACET. ACEP is a glycoprotein expressed in vascular endothelial cells of the lung, liver, adrenal cortex, pancreas, kidney and spleen. The ACET isoform is expressed exclusively in adult testis by developing sperm cells, specifically late pachytene spermatocytes. Additionally, ACE inactivates bradykinin, a vasodepressor peptide, and is involved in blood pressure regulation and fluid/electrolyte homeostasis. ACE2 is the first known human homolog of ACE. Unlike ACE, which is expressed ubiquitously throughout the vasculature, ACE2 is expressed only in cardiac, renal and testicular cells.
WB: 1:1,000-5,000; IHC: 1:50-1:200; ICC: 1:100-1:500
For Research Use Only. Not for use in diagnostic/therapeutics procedures.