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  7. Anti-C1QB / Complement C1q B-Chain Monoclonal Antibody(Clone: C1QB/2961)

Anti-C1QB / Complement C1q B-Chain Monoclonal Antibody(Clone: C1QB/2961)

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Fig. 1: Formalin-fixed, paraffin-embedded human Hepatocellular Carcinoma stained with C1QB Mouse Monoclonal Antibody (C1QB/2961).

Anti-C1QB / Complement C1q B-Chain Monoclonal Antibody(Clone: C1QB/2961)
Anti-C1QB / Complement C1q B-Chain Monoclonal Antibody(Clone: C1QB/2961)
Anti-C1QB / Complement C1q B-Chain Monoclonal Antibody(Clone: C1QB/2961)

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Fig. 1: Formalin-fixed, paraffin-embedded human Hepatocellular Carcinoma stained with C1QB Mouse Monoclonal Antibody (C1QB/2961).
Fig. 2: SDS-PAGE Analysis Purified C1QB Mouse Monoclonal Antibody (C1QB/2961). Confirmation of Purity and Integrity of Antibody.
Fig. 3: Analysis of Protein Array containing more than 19,000 full-length human proteins using C1QB Mouse Monoclonal Antibody (C1QB/2961). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (Monoclonal Antibody) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a Monoclonal Antibody to its intended target. A Monoclonal Antibody is considered to specific to its intended target, if the Monoclonal Antibody has an S-score of at least 2.5. For example, if a Monoclonal Antibody binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that Monoclonal Antibody to protein X is equal to 29.

Product code: 36-3284

Clone name : C1QB/2961
Clonality : Monoclonal
Application : IHC
Reactivity : Human

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  • Product Info
  • Antigen Details
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Amount : 100 µg
Isotype : Mouse IgG1, kappa
Content : 200 µg/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Storage condition : Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous.
Gene : C1QB
Gene ID : 713
Uniprot ID : P02746
Alternative Name : C1QB; Complement component 1 q subcomponent B chain; Complement component C1q B chain
Immunogen Information : Recombinant fragment (around aa 41-188) of human C1QB protein (exact sequence is proprietary)
C1q, a subcomponent of the classical complement pathway, is composed of nine subunits that mediate classical complement activation and thereby play an important role in the immune response. Six of these subunits are disulfide-linked dimers of chains A and B, while three of these subunits, designated C1q-A throµgh C1q-C, are disulfide-linked dimers of chain C. Each chain contains an N-terminal collagen-like region and a C-terminal C1q globular domain. The presence of receptors for C1q on effector cells modulates its activity, which may be antibody-dependent or independent. Macrophages are the primary source of C1q, while anti-inflammatory drµgs as well as cytokines differentially regulate expression of the mRNA as well as the protein. C1q deficiency is associated with lupus erythematosus and glomerulonephritis.

Immunohistochemistry (Formalin-fixed) (1-2µg/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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Anti-C1QB / Complement C1q B-Chain Monoclonal Antibody(Clone: C1QB/2961)

Product code: 36-3284
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