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  7. Anti-Caldesmon, HMW (h-Caldesmon) (Smooth Muscle Marker) Recombinant Mouse Monoclonal Antibody (Clone:rCALD1/820)

Anti-Caldesmon, HMW (h-Caldesmon) (Smooth Muscle Marker) Recombinant Mouse Monoclonal Antibody (Clone:rCALD1/820)

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Figure 1: Formalin-fixed, paraffin-embedded human Leiomyosarcoma stained with Caldesmon Mouse Recombinant Monoclonal Antibody (rCALD1/820).

Anti-Caldesmon, HMW (h-Caldesmon) (Smooth Muscle Marker) Recombinant Mouse Monoclonal Antibody (Clone:rCALD1/820)
Anti-Caldesmon, HMW (h-Caldesmon) (Smooth Muscle Marker) Recombinant Mouse Monoclonal Antibody (Clone:rCALD1/820)

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Figure 1: Formalin-fixed, paraffin-embedded human Leiomyosarcoma stained with Caldesmon Mouse Recombinant Monoclonal Antibody (rCALD1/820).
Figure 2: SDS-PAGE Analysis of Purified Caldesmon Mouse Recombinant Monoclonal Antibody (rCALD1/820).

Product code: 12-1085

Clone name : rCALD1/820
Clonality : Monoclonal
Application : IHC, WB
Reactivity : Human

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  •  100 µg

  • $249.00 

  • $499.00 

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Format : Purified
Amount : 100 µg
Isotype : Mouse IgG1, kappa
Purification : Protein A/G
Content : 200µg/ml of recombinant MAb purified by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Storage condition : Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous.
Gene : CALD1
Gene ID : 800
Uniprot ID : Q05682
Alternative Name : CAD; CALD1; Caldesmon 1 Isoform 1; Caldesmon 1 Isoform 2; Caldesmon 1 Isoform 3; Caldesmon 1 Isoform 4; Caldesmon 1 Isoform 5; CDM; HCAD; LCAD; NAG22
Immunogen Information : Recombinant full-length human CALD1 protein

Recognizes a protein of 150kDa, which is identified as the high molecular weight variant of Caldesmon. Two closely related variants of human caldesmon have been identified which are different in their electrophoretic mobility and cellular distribution. The h-caldesmon variant (120-150kDa) is predominantly expressed in smooth muscle whereas l-caldesmon (70-80kDa) is found in non- muscle tissue and cells. Neither of the two variants has been detected in skeletal muscle. This MAb recognizes only the 150kDa variant (h-caldesmon) in Western blots of human aortic media extracts and is unreactive with fibroblast extracts from cultivated human foreskin. Caldesmon is a developmentally regulated protein involved in smooth muscle and non-muscle contraction.

Western Blot (1-2µg/ml); ,Immunohistology (Formalin-fixed) (0.25-0.5µg/ml for 30 minutes at RT),(Staining of formalin-fixed tissues requires boiling tissue sections in 1mM EDTA, pH 7.5-8.5, for 10-20 min followed by cooling at RT for 20 minutes),

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Cytoplasm, Cytoplasm, Cytoplasm
Post transnational modification: In non-muscle cells, phosphorylation by CDK1 during mitosis causes caldesmon to dissociate from microfilaments. Phosphorylation reduces caldesmon binding to actin, myosin, and calmodulin as well as its inhibition of actomyosin ATPase activity. Phosphorylation also occurs in both quiescent and dividing smooth muscle cells with similar effects on the interaction with actin and calmodulin and on microfilaments reorganization. CDK1-mediated phosphorylation promotes Schwann cell migration during peripheral nerve regeneration (By similarity).
Tissue Specificity: High-molecular-weight caldesmon (isoform 1) is predominantly expressed in smooth muscles, whereas low-molecular-weight caldesmon (isoforms 2, 3, 4 and 5) are widely distributed in non-muscle tissues and cells. Not expressed in skeletal muscle or heart.
BioGrid: 107251. 49 interactions.
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Anti-Caldesmon, HMW (h-Caldesmon) (Smooth Muscle Marker) Recombinant Mouse Monoclonal Antibody (Clone:rCALD1/820)

Product code: 12-1085
*specify in mg or ml

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