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  7. 36-3452

Anti-CD1a / HTA1 (Mature Langerhans Cells Marker) Monoclonal Antibody(Clone: rC1A/711)

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Anti-CD1a / HTA1 (Mature Langerhans Cells Marker) Monoclonal Antibody(Clone: rC1A/711)

Fig. 1: Formalin-fixed, paraffin-embedded human Skin stained with CD1a Mouse Recombinant Monoclonal Antibody (rC1A/711).

Anti-CD1a / HTA1 (Mature Langerhans Cells Marker) Monoclonal Antibody(Clone: rC1A/711)
Anti-CD1a / HTA1 (Mature Langerhans Cells Marker) Monoclonal Antibody(Clone: rC1A/711)
Anti-CD1a / HTA1 (Mature Langerhans Cells Marker) Monoclonal Antibody(Clone: rC1A/711)
Anti-CD1a / HTA1 (Mature Langerhans Cells Marker) Monoclonal Antibody(Clone: rC1A/711)

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Fig. 1: Formalin-fixed, paraffin-embedded human Skin stained with CD1a Mouse Recombinant Monoclonal Antibody (rC1A/711).
   
Fig. 1: Formalin-fixed, paraffin-embedded human Skin stained with CD1a Mouse Recombinant Monoclonal Antibody (rC1A/711).
Fig. 2: Formalin-fixed, paraffin-embedded human Skin stained with CD1a Mouse Recombinant Monoclonal Antibody (rC1A/711).
Fig. 3: SDS-PAGE Analysis Purified CD1a Mouse Recombinant Monoclonal Antibody (rC1A/711). Confirmation of Purity and Integrity of Antibody.
Fig. 4: Analysis of Protein Array containing more than 19,000 full-length human proteins using CD1a-Monospecific Recombinant Mouse Monoclonal Antibody (rC1A/711) Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.

Product code: 36-3452

Clone name : rC1A/711
Application : IHC
Reactivity : Human

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  •   20 µg

  •  100 µg

  • $199.00 

  • $429.00 

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  • Antigen Details
  • Description
  • Product Info
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Gene : CD1A
Gene ID : 909
Uniprot ID : P06126
Alternative Name : Cortical thymocyte antigen CD1A, Epidermal dendritic cell marker CD1a antibody, FCB6, HTA1, T cell surface antigen T6 / Leu 6, T-Cell Surface Glycoprotein CD1A
Amount : 100 µg
Isotype : Mouse IgG1, kappa
Immunogen Information : Recombinant full-length human CD1a protein
At least five CD1 genes (CD1a, b, c, d, and e) are identified. CD1 proteins have been demonstrated to restrict T cell response to non-peptide lipid and glycolipid antigens and play a role in non-classical antigen presentation. CD1a is a non-polymorphic MHC Class 1 related cell surface glycoprotein, expressed in association with Beta-2 microglobulin. Anti-CD1a labels Langerhans cell histiocytosis (Histiocytosis X), extranodal histiocytic sarcoma, a subset of T-lymphoblastic lymphoma/leukemia, and interdigitating dendritic cell sarcoma of the lymph node. When combined with antibodies against TTF-1 and CD5, anti-CD1a is useful in distinguishing between pulmonary and thymic neoplasms since CD1a is consistently expressed in thymic lymphocytes in both typical and atypical thymomas, but only focally in 1/6 of thymic carcinomas and not in lymphocytes in pulmonary neoplasms. Anti-CD1a is reported to be a new marker for perivascular epithelial cell tumor (PEComa).
Content : 200 µg/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Storage condition : Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous.

Immunohistochemistry (Formalin-fixed) (0.5-1µg/ml for 30 min at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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Anti-CD1a / HTA1 (Mature Langerhans Cells Marker) Monoclonal Antibody(Clone: rC1A/711)

Product code: 36-3452
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