Anti-CD273 / PD-L2 Monoclonal Antibody (Clone:24F.10C12) Biotin Conjugated
Figure 1: Flow cytometry multicolor surface staining pattern of human stimulated (GM-CSF + IL-4) leukocytes stained using anti-human CD11c (BU15) PE antibody (20 μl reagent / 100 μl of peripheral whole blood) and anti-human CD273 (24F.10C12) biotin antibody (concentration in sample 1.67 μg/ml, Streptavidin APC).
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| Format : | Purified |
| Amount : | 0.1 mg |
| Isotype : | Mouse IgG2a kappa |
| Purification : | Purified antibody is conjugated with biotin LC-NHS ester under optimum conditions and unconjugated antibody and free biotin are removed by size-exclusion chromatography. |
| Content : | Stprage Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide |
| Storage condition : | Store at 2-8°C. Do not freeze. |
Specificity: The mouse monoclonal antibody 24F.10C12 recognizes an extracellular epitope of CD273 / PD-L2 (also known as B7-DC), a 25 kDa type I transmembrane protein expressed by dendritic cells, activated monocytes and T cells, heart, first trimester placenta, lung and liver, as well as in Hodgkin´s lymphoma cells and primary mediastinal B cell lymphoma (PMBL).
Description: CD273 / PD-L2 (programmed death ligand-1), also known as B7-DC, is a member of the B7 family of regulatory proteins. It costimulates the proliferation of T cells, and mediates IFN gamma production. Ligation of CD273 on dendritic cells enhances dendritic cell activation and T cell responses. When interacting with CD279, it can act as a coinhibitor of the T cell function. CD273 expression is a useful marker to distinguish primary mediastinal B cell lymphoma from other diffuse large B cell lymphomas.
Flow cytometry: Recommended dilution: 1-5 μg/ml
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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