Recombinant Human Retinol-Binding Protein 4/RBP4 (C-His)
Figure 1 : Recombinant Human RBP4 Protein (His Tag), verified image
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| Amount : | 25 µg |
| Purification : | ≥ 85 % as determined by SDS-PAGE. ≥ 90 % as determined by SEC-HPLC. |
| Content : | Formulation: Lyophilized from sterile PBS, pH 7.2 Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. |
| Storage condition : | Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
| AA sequence : | Predicted N Terminal: Glu 19 |
| Alternative Name : | Plasma retinol-binding protein; RBP4; retinol binding protein 4, plasma; RetinolBinding Protein 4; retinol-binding protein 4;Plasma retinol-binding protein Plasma retinol-binding protein(1-182) Plasma retinol-binding protein(1-181) Plasma retinol-binding protein(1-179) Plasma retinol-binding protein(1-176) |
Source: Human 293 Cells;
Specificity : Detected in blood plasma and in urine (at protein level).
Retinol-binding protein 4 (RBP4) is the specific carrier for retinol (alsoknown as vitamin A), and is responsible for the conversionof unstableandinsoluble retinol in aqueous solution into stable and solublecomplexinplasma through their tight interaction. As a member of thelipocalinsuperfamily, RBP4 containing a β-barrel structure with a well-definedcavityis secreted from the liver, and in turn delivers retinol fromtheliver storestothe peripheral tissues. In plasma, the RBP4-retinol complexinteractswithtransthyretin (TTR), and this binding is crucial for preventingRBP4excretion through the kidney glomeruli. RBP4 expressedfromanectopicsource efficiently delivers retinol to the eyes, and its deficiencyaffectsnightvision largely. Recently, RBP4 as an adipokine, is found tobeexpressedinadipose tissue and correlated with obesity, insulin resistance(IR) andtype2 diabetes (T2DM).
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