Anti-CD146 Monoclonal Antibody (Clone:P1H12)-Alexa Fluor 488

Product code: 30-1566AF488

Clone name : P1H12
Clonality : Monoclonal
Application : FACS
Reactivity : Dog, Mouse, Human, Rabbit
Conjugate : FITC

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100 tests

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Amount : 100 tests
Isotype : Mouse IgG1
Storage condition : Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light.
Gene : MCAM
Gene ID : 4162
Uniprot ID : P43121
Alternative Name : MCAM, MUC18
Immunogen Information : cultured human umbilical cells

CD146, also known as MCAM (melanoma cell adhesion molecule) or MUC18, is a heavily glycosylated transmembrane glycoprotein with more than 50% of the mass from carbohydrates. It is expressed on epithelial and endothelial cells, fibroblasts, multipotent mesenchymal stromal cells, activated T cells and activated keratinocytes, and on some cancer cells, especially melanoma. The presence of CD146 on circulating blood cells has been confined to the activated T cells rather than circulating endothelial cells. CD146 mediates heterophilic cell adhesion and regulates monocyte transendothelial migration.

Flow cytometry: The reagent is designed for analysis of human blood cells using 4 μl reagent / 100 μl of whole blood or 106 cells in a suspension. The content of a vial (0.4 ml) is sufficient for 100 tests.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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