Anti-CD274 / PD-L1 Monoclonal Antibody (Clone:29E.2A3)-Biotin Conjugated
Figure 1: Flow cytometry surface staining pattern of stimulated (GM-CSF + IL-4) human mononuclear cells stained using anti-human CD274 (29E.2A3) Biotin antibody (concentration in sample 0.56 μg/ml, Streptavidin APC).
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| Amount : | 0.1 mg |
| Isotype : | Mouse IgG2b kappa |
| Purification : | Purified antibody is conjugated with biotin LC-NHS ester under optimum conditions and unconjugated antibody and free biotin are removed by size-exclusion chromatography. |
| Content : | Concentration: 1 mg/ml Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide |
| Storage condition : | Store at 2-8°C. Do not freeze. |
Specificity: The mouse monoclonal antibody 29E.2A3 recognizes an extracellular epitope of CD274 / PD-L1 (also known as B7-H1), a 40 kDa type I transmembrane protein expressed by dendritic cells, activated T cells, activated monocytes, and in various tissues, above all in heart and skeletal muscle, placenta and lung, and in many cancer cells, including T cell lymphomas, melanomas, and glioblastomas.
Desciption: CD274 / PD-L1 (programmed death ligand-1), also known as B7-H1, is a member of the B7 family of regulatory proteins. It can act as both costimulatory and coinhibitory molecule for T cells. Interaction with its ligand CD279 (PD1) appears to be important in the maintenance of peripheral tolerance and in prevention of tumor rejection. Even pathogens (e.g. Schistosoma) may exploit CD274 to evade an immune response. Besides CD279, existence of other receptor(s) for CD274 is likely.
Flow cytometry: Recommended dilution: 0.5-4 μg/ml.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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