Anti-CD39 Monoclonal Antibody (Clone:TU66)-PE Conjugated

Product code: 30-2150

Clone name : TU66
Clonality : Monoclonal
Application : FACS
Reactivity : Human
Conjugate : PE

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100 tests

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Amount : 100 tests
Isotype : Mouse IgG2b
Storage condition : Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light.
Gene : ENTPD1
Gene ID : 953
Uniprot ID : P49961
Alternative Name : Ecto-ATP diphosphohydrolase 1, Ecto-ATPDase 1, Lymphoid cell activation antigen

CD39, also known as ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1), is a cell surface enzyme (with intracellular N- and C-terminus) which hydrolyzes extracellular ATP and ADP to AMP. Inhibition of its enzymatic activity may confer anticancer benefits. The formation of oligomers in the plasma membrane is essential for enzyme activity. It is expressed on Treg cells, and in other cell types, such as mantle zone B cells, activated T cells, NK cells, macrophages, dendritic cells, neurons, endothelial cells and platelets. Hydrolysis of ATP and ADP inhibits inflammatory and thrombotic responses. In the nervous system, it regulates purinergic neurotransmission.

Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μl reagent / 100 μl of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Membrane
Post transnational modification: Palmitoylated in the N-terminal part.
Tissue Specificity: Expressed primarily on activated lymphoid cells. Also expressed in endothelial tissues. Isoform 1 and isoform 3 are present in both placenta and umbilical vein, whereas isoform 2 is present in placenta only.
BioGrid: 107391. 2 interactions.
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