Anti-CTLA-4 Monoclonal Antibody (Clone:IHC004)-Ready to Use
|Amount :||7 ml|
|Purification :||Protein A/G Chromatography|
|Content :||Tris Buffer, pH 7.3 - 7.7, with 1% BSA and <0.1% Sodium Azide|
|Storage condition :||Store at 2°C - 8°C. Do not freeze.|
"Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) is a receptor on T Helper cells that functions as an immune checkpoint and downregulator of immune responses. Mutations in CTLA-4 are associated with insulin-dependent diabetes mellitus, Hashimoto’s thyroiditis, Graves’ disease, systemic lupus erythematosus (SLE), celiac disease, primary biliary cirrhosis, thyroid-associated orbitopathy, multiple sclerosis, and other autoimmune diseases. The spliced variant of CTLA-4 in SLE is present in the patient’s serum. Haploinsufficiency of CTLA-4 causes the immune system disorder known as CTLA-4 deficiency or CHAI disease (CTLA4 haploinsufficiency with autoimmune infiltration)."
This product is available in ready to use format, hence no dilution is required.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
|Subcellular location:||Cell membrane|
|Post transnational modification:||Phosphorylation at Tyr-201 prevents binding to the AP-2 adapter complex, blocks endocytosis, and leads to retention of CTLA4 on the cell surface.|
|Tissue Specificity:||Widely expressed with highest levels in lymphoid tissues. Detected in activated T-cells where expression levels are 30- to 50-fold less than CD28, the stimulatory coreceptor, on the cell surface following activation.|
|BioGrid:||107875. 109 interactions.|