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  7. Anti-Cytokeratin 7+17 Monoclonal Antibody (Clone:C-46)

Anti-Cytokeratin 7+17 Monoclonal Antibody (Clone:C-46)

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Figure-1: Immunohistochemistry staining of pancreas (paraffin-embedded sections) with anti-Cytokeratin 7+17 (C-46).

Anti-Cytokeratin 7+17 Monoclonal Antibody (Clone:C-46)
Anti-Cytokeratin 7+17 Monoclonal Antibody (Clone:C-46)
Anti-Cytokeratin 7+17 Monoclonal Antibody (Clone:C-46)

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Figure-1: Immunohistochemistry staining of pancreas (paraffin-embedded sections) with anti-Cytokeratin 7+17 (C-46).
Figure-2: Immunohistochemistry staining of human breast (paraffin-embedded sections) with anti-cytokeratin 7+17 (C-46).
Figure-3: Western blotting analysis of human cytokeratin 7+17 using mouse monoclonal antibody C-46 on lysates of HeLa cell line and Jurkat cell line (cytokeratin non-expressing cell line; negative control) under non-reducing and reducing conditions. Nitrocellulose membrane was probed with 2 µg/ml of mouse anti-cytokeratin 7+17 monoclonal antibody C-46 followed by IRDye800-conjugated anti-mouse IgG1 secondary antibody. A specific band was detected for cytokeratin 17 at approximately 46 kDa and for cytokeratin 7 at approximately 54 kDa.

Product code: 30-1044

Clone name : C-46
Clonality : Monoclonal
Application : IP
Reactivity : Pig

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  • Product Info
  • Antigen Details
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Format : Purified
Amount : 0.1 mg
Isotype : Mouse IgG1
Purification : Purified by protein-A affinity chromatography
Storage condition : Store at 2-8°C. Do not freeze.
Gene : KRT17
Gene ID : 3872
Uniprot ID : Q04695
Alternative Name : KRT17
Immunogen Information : Cytoskeleton preparation of HeLa human cervix carcinoma cell line.

Cytokeratins are a subfamily of intermediate filaments and characterized by remarkable biochemical diversity. Cytokeratins are represented in epithelial tissues by at least 20 different polypeptides, molecular weight between 40 kDa and 68 kDa. The individual cytokeratin polypeptides are designated 1 to 20 and divided into the type I (acidic cytokeratins 9-20) and type II (basic to neutral cytokeratins 1-8) families.

Immunohistochemistry (paraffin sections): Recommended dilution: 10 μg/ml, pretreatment: 0,1% pepsin, 30 min, 37°C, incubation 4°C overnight, chromogen DAB; positive tissue: pancreas.
Western blotting: Recommended dilution: 1-2 μg/ml; positive control: HeLa cells.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Cytoplasm
Post transnational modification: Phosphorylation at Ser-44 occurs in a growth- and stress-dependent fashion in skin keratinocytes, it has no effect on filament organization.
Tissue Specificity: Expressed in the outer root sheath and medulla region of hair follicle specifically from eyebrow and beard, digital pulp, nail matrix and nail bed epithelium, mucosal stratified squamous epithelia and in basal cells of oral epithelium, palmoplantar epidermis and sweat and mammary glands. Also expressed in myoepithelium of prostate, basal layer of urinary bladder, cambial cells of sebaceous gland and in exocervix (at protein level).
BioGrid: 110070. 42 interactions.
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Anti-Cytokeratin 7+17 Monoclonal Antibody (Clone:C-46)

Product code: 30-1044
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