Anti-E. coli K99 pili (Clone K9912-444.5)
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| Amount : | 100 µg |
| Isotype : | Mouse IgG1 |
| Purification : | Product preparation: Produced under comprehensive ISO 9001 and ISO 13485 quality controls, our antibody preparation guarantees superior lot-to-lot consistency; This product is manufactured in St. Louis, Missouri USA. Each batch is isolated through a specialized multi-step purification cascade that incorporates automated Protein G or Protein A chromatography. This process actively eliminates interfering contaminants, yielding a highly stable antibody with ultra-low endotoxin specifications, trace leachable protein A, and virtually no aggregate artifacts. |
| Content : | Concentration: Lot Specific Formulation: This monoclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.2 - 7.4 with no carrier protein or preservatives added. |
| Storage condition : | Upon initial thawing, appropriately aliquot and store at -20°C to -70°C. For long-term storage, keep at -20°C to -70°C. Avoid repeated freeze-thaw cycles. |
| Immunogen Information : | Purified E. coli K99 (B44) pili |
Specificity
The Clone K9912-444.5 antibody exhibits high specificity for K99+ E. coli. Crucially for diagnostic assay development, this mouse monoclonal antibody demonstrates no cross-reactivity with K99-negative E. coli (B41), E. coli K88ac, E. coli 987P, Proteus mirabilis, Proteus vulgaris, Pseudomonas aeruginosa, Enterobacter aerogenes, Citrobacter freundii, Klebsiella pneumoniae, or Strep. agalactiae.
Background
Bovine enteric colibacillosis is an economically important disease in neonatal calves caused by enterotoxigenic E. coli (ETEC) which adhere to intestinal cells using pili. Most ETEC isolated from cattle use K99 pili to bind to enterocytes of the small intestine. K99 pili are primarily composed of a repeating 18.2kDa major subunit which is responsible for binding to host glycoprotein receptor, N-glycolylneuraminic acid-GM3. A 7.1kb operon of eight genes on a plasmid encode the pili and other associated proteins responsible for regulation, transport, and assembly of K99 pili.
These antibodies have been qualified for use in ELISA to detect K99+ E. coli.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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