Anti-HLA-A+B+C+E Monoclonal Antibody (Clone:TP25.99SF)
Shipping Info:
For estimated delivery dates, please contact us at support@abeomics.com
Format : | Purified |
Amount : | 0.1 mg |
Isotype : | Mouse IgG1 |
Purification : | Purified from hybridoma culture supernatant by protein-A affinity chromatography. |
Storage condition : | Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze. |
Immunogen Information : | IFN-gamma-treated human melanoma cells Colo 38 |
HLA-class I major histocompatibility (MHC) antigens are intrinsic membrane glycoproteins expressed on nucleated cells and noncovalently associated with an invariant beta2 microglobulin. They carry foreign determinants important for immune recognition by cytotoxic T cells, thus important for anti-viral and anti-tumour defence. Classical human HLA-class I antigens are represented by HLA-A, HLA-B and HLA-C molecules, the non-classical by e.g. HLA-E, HLA-G.
Subcellular location: | Membrane |
Post transnational modification: | Polyubiquitinated in a post ER compartment through interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system. |
BioGrid: | 109350. 90 interactions. |
There are currently no product reviews
|