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    7. Anti-HSP60 Monoclonal Antibody (Clone : LK2)

    Anti-HSP60 Monoclonal Antibody (Clone : LK2)

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    Figure1 : Mouse Anti-Hsp60 Antibody [LK-2] used in Immunohistochemistry (IHC) on Human colon carcinoma

    Anti-HSP60 Monoclonal Antibody (Clone : LK2)
    Anti-HSP60 Monoclonal Antibody (Clone : LK2)
    Anti-HSP60 Monoclonal Antibody (Clone : LK2)

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    Figure1 : Mouse Anti-Hsp60 Antibody [LK-2] used in Immunohistochemistry (IHC) on Human colon carcinoma
    Figure 2 :  Mouse Anti-Hsp60 Antibody [LK-2] used in Immunohistochemistry (IHC) on Mouse backskin
    Figure 3 :  Mouse Anti-Hsp60 Antibody [LK-2] used in Western Blot (WB) on Human Heat Shocked HeLa cell lysates

    Product code: 42-1127

    Clone name : LK2
    Clonality : Monoclonal
    Application : IHC, WB
    Reactivity : Pig, Monkey, Dog, Rat, Mouse, Human, Bovine, Rabbit
    Conjugate : Unconjugated

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    •   50 µg

    •  200 µg

    • $268.00 

    • $360.00  $288.00 

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    • Product Info
    • Antigen Details
    • Description
    • Application Note
    • Review   (0)
    Amount : 200 µg
    Isotype : Mouse IgG1
    Purification : Protein G Purified
    Content : PBS, 50% glycerol, 0.1mM PMSF
    Storage condition : Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.
    Gene : HSPD1
    Gene ID : 3329
    Uniprot ID : P10809
    Alternative Name : HSPD1, HSP60
    Immunogen Information : Recombinant human HSP60

    In both prokaryotic and eukaryotic cells, the misfolding and aggregation of proteins during biogenesis and under conditions of cellular stress are prevented by molecular chaperones. Members of the HSP60 family of heat shock proteins are some of the best characterized chaperones. HSP60, also known as Cpn60 or GroEl, is an abundant protein synthesized constitutively in the cell that is induced to a higher concentration after brief cell shock. It is present in many species and exhibits a remarkable sequence homology among various counterparts in bacteria, plants, and mammals with more than half of the residues identical between bacterial and mammalian HSP60. Whereas mammalian HSP60 is localized within the mitochondria, plant HSP60, or otherwise known as Rubisco-binding protein, is located in plant chloroplasts. It has been indicated that these proteins carry out a very important biological function due to the fact that HSP60 is present in so many different species. The common characteristics of the HSP60s from the divergent species are i) high abundance, ii) induction with environmental stress such as heat shock, iii) homo-oligomeric structures of either 7 or 14 subunits which reversibly dissociate in the presence of Mg2+ and ATP, iv) ATPase activity and v) a role in folding and assembly of oligomeric protein structures. These similarities are supported by recent studies where the single-ring human mitochondrial homolog, HSP60 with its co-chaperonin, HSP10 were expressed in a E. coli strain, engineered so that the groE operon is under strict regulatory control. This study has demonstrated that expression of HSP60-HSP10 was able to carry out all essential in vivo functions of GroEL and its co-chaperonin, GroES. Another important function of HSP60 and HSP10 is their protective functions against infection and cellular stress. HSP60 has however been linked to a number of autoimmune diseases, as well as Alzheimer's, coronary artery diseases, MS, and diabetes.

    WB (1:4000), IHC (1:100); optimal dilutions for assays should be determined by the user.

    For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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    Anti-HSP60 Monoclonal Antibody (Clone : LK2)

    Product code: 42-1127
    *specify in mg or ml

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