Anti-HSP90 Monoclonal Antibody (Clone: AC-16)(Discontinued)

Product code: 39-1044

Clone name : AC-16
Clonality : Monoclonal
Application : WB
Reactivity : Human

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Amount : 100 μg/vial
Isotype : Mouse IgG2b
Purification : Ascites
Content : Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative. Reconstitute : Add 1ml of PBS buffer will yield a concentration of 100ug/ml.
Storage condition : At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.
Gene : Hsp90ab1
Gene ID : 301252
Uniprot ID : P34058
Alternative Name : Heat shock protein HSP 90-beta; Heat shock 84 kDa; HSP 84; HSP84; Hsp90ab1; Hsp84, Hspcb
Immunogen Information : Heat shock protein 90(HSP90) from the water mold Achlya ambisexualis.

Heat Shock Protein 90(HSP70) exists in multiple forms in mammalian cells. It has a unique 30-amino acid N terminus instead of the 223-amino acid ATP/geldanamycin-binding domain found at the N terminus of full-length HSPCA, which contains 732 amino acids. Functional proteomic screens reveal an essential extracellular role for hsp90-alpha in cancer cell invasiveness.

Western blot : 2-4μg/ml

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Cytoplasm, Melanosome, Nucleus, Secreted, Cell membrane
Post transnational modification: Cleaved following oxidative stress resulting in HSP90AB1 protein radicals formation; disrupts the chaperoning function and the degradation of its client proteins.
BioGrid: 256892. 6 interactions.
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