Anti-HSP90 Monoclonal Antibody (Clone: AC-16)(Discontinued)
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|Amount :||100 μg/vial|
|Isotype :||Mouse IgG2b|
|Content :||Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative. Reconstitute : Add 1ml of PBS buffer will yield a concentration of 100ug/ml.|
|Storage condition :||At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.|
Heat Shock Protein 90(HSP70) exists in multiple forms in mammalian cells. It has a unique 30-amino acid N terminus instead of the 223-amino acid ATP/geldanamycin-binding domain found at the N terminus of full-length HSPCA, which contains 732 amino acids. Functional proteomic screens reveal an essential extracellular role for hsp90-alpha in cancer cell invasiveness.
Western blot : 2-4μg/ml
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
|Subcellular location:||Cytoplasm, Melanosome, Nucleus, Secreted, Cell membrane|
|Post transnational modification:||Cleaved following oxidative stress resulting in HSP90AB1 protein radicals formation; disrupts the chaperoning function and the degradation of its client proteins.|
|BioGrid:||256892. 6 interactions.|
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