Anti-Human CD276 Monoclonal Antibody (Clone: 7-517)
Figure 1: Flow cytometry surface staining pattern of human stimulated (GM-CSF + IL-4) monocytes stained using anti-human CD276 (7-517) purified antibody (concentration in sample 0.19 μg/ml) GAM APC.
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| Format : | Purified |
| Amount : | 0.1 mg |
| Isotype : | Mouse IgG1 kappa |
| Purification : | Purified by protein-A affinity chromatography. |
| Content : | Concentration: 1 mg/ml Formulation: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide |
| Storage condition : | Store at 2-8°C. Do not freeze. |
Specificity: The mouse monoclonal antibody 7-517 recognizes an extracellular epitope of human CD276 (B7H3) transmembrane glycoprotein.
Background: CD276 (B7H3) is a type I transmembrane glycoprotein expressed on dendritic cells, osteoblasts, sinonasal epithelium, and upon activation (by inflammatory cytokines) in monocytes, NK cells, T cells and B cells. Although it has been described also as a costimulatory ligand, its major role seems to be inhibitory. It regullates T cell proliferation and functions, and may provide certain tumors with protection against NK cells. CD276 can be used as a marker of neuroblastoma cells in the bone marrow, which is the primary site of neuroblastoma relapse.
CD276 (B7H3) is a type I transmembrane glycoprotein expressed on dendritic cells, osteoblasts, sinonasal epithelium, and upon activation (by inflammatory cytokines) in monocytes, NK cells, T cells and B cells. Although it has been described also as a costimulatory ligand, its major role seems to be inhibitory. It regullates T cell proliferation and functions, and may provide certain tumors with protection against NK cells. CD276 can be used as a marker of neuroblastoma cells in the bone marrow, which is the primary site of neuroblastoma relapse.
Flow cytometry: Recommended dilution: 0.5-4 μg/ml.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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