Anti-Human CD100 Antibody (Clone : 133-1C6)
Figure 1 : Flow cytometry analysis (surface staining) of human peripheral blood with anti-CD100 (133-1C6) purified, GAM-APC.
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| Format : | Purified |
| Amount : | 0.1 mg |
| Isotype : | Mouse IgM |
| Purification : | Purified by protein-A affinity chromatography |
| Content : | 1 mg/ml Formulation : Tris buffered saline (TBS), pH 8.0, 15 mM sodium azide |
| Storage condition : | Store at 2-8°C. Do not freeze. |
| Gene : | SEMA4D |
| Gene ID : | 10507 |
| Alternative Name : | COLL4, SEMA4D, semaphorin 4D,semaphorin 4D |
| Immunogen Information : | PHA stimulated human PBL |
CD100, also known as Semaphorin 4D, is a homodimerizing type I transmembrane glycoprotein containing an extracellular semaphorin domain. It is expressed on most hematopoietic cells with the exception of immature bone marrow cells, erythrocytes and platelets. A 120 kDa soluble form is generated from the transmembrane form by proteolytic cascade following primary T and B cell activation. It seems CD100 acts through dampening CD72-mediated negative signaling. CD100 promotes angiogenesis, invasive growth, proliferation and anti-apoptosis of cancer cells in vitro. Higher expression levels of CD100 correlate with poor survival in soft tissue sarcoma patients.
Specificity : The mouse monoclonal antibody 133-1C6 recognizes an extracellular epitope of CD100, an approximately 150 kDa (when reduced) semaphorin family member expressed mainly on lymphocytes, NK cells, monocytes/macrophages and granulocytes, but also on some non-hematopoietic cells.
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