Anti-Human CD100 Antibody (Clone : 133-1C6)

Product code: 30-2668

Clone name : 133-1C6
Clonality : Monoclonal
Reactivity : Human

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0.1 mg
$389.00 

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Format : Purified
Amount : 0.1 mg
Isotype : Mouse IgM
Purification : Purified by protein-A affinity chromatography
Content : 1 mg/ml
Formulation : Tris buffered saline (TBS), pH 8.0, 15 mM sodium azide
Storage condition : Store at 2-8°C. Do not freeze.
Gene : SEMA4D
Gene ID : 10507
Alternative Name : COLL4, SEMA4D, semaphorin 4D,semaphorin 4D
Immunogen Information : PHA stimulated human PBL

CD100, also known as Semaphorin 4D, is a homodimerizing type I transmembrane glycoprotein containing an extracellular semaphorin domain. It is expressed on most hematopoietic cells with the exception of immature bone marrow cells, erythrocytes and platelets. A 120 kDa soluble form is generated from the transmembrane form by proteolytic cascade following primary T and B cell activation. It seems CD100 acts through dampening CD72-mediated negative signaling. CD100 promotes angiogenesis, invasive growth, proliferation and anti-apoptosis of cancer cells in vitro. Higher expression levels of CD100 correlate with poor survival in soft tissue sarcoma patients.
Specificity : The mouse monoclonal antibody 133-1C6 recognizes an extracellular epitope of CD100, an approximately 150 kDa (when reduced) semaphorin family member expressed mainly on lymphocytes, NK cells, monocytes/macrophages and granulocytes, but also on some non-hematopoietic cells.

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