Anti-Human CX3CR1 Monoclonal Antibody (Clone:2A9-1) APC Conjugated
Fig 1: Flow cytometry surface staining pattern of human peripheral whole blood stained using anti-human CX3CR1 (2A9-1) APC antibody (concentration in sample 0.56 μg/ml).
Roll over image to zoom in
Shipping Info:
For estimated delivery dates, please contact us at [email protected]
| Amount : | 100 Tests |
| Isotype : | Rat IgG2b kappa |
| Purification : | Purified antibody is conjugated with activated allophycocyanin (APC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography. |
| Content : | Formulation: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide |
| Storage condition : | Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze. |
Specificity: The rat monoclonal antibody 2A9-1 recognizes an extracellular epitope of CX3CR1, an important regulator of leukocyte trafficking and immune system ballance.
Description: CX3CR1 (fractalkine receptor) serves as a regulator of leukocyte trafficking. Its ligand CX3CL1 (fractalkine) can serve bots as chemoatractant (soluble) and as adhesive molecule (membrane bound). Binding to the cell surface expressed ligand leads to rapid induction of firm adhesion of CX3CR1-positive cells without requiring selectin-mediated rolling or activation of integrins. This interaction is important for trafficking of cytotoxic effector lymphocytes regardless of their lineage and mode of target cell recognition, through inflamed endothelium. Similarly, it mediates monocyte/macrophage recruitment to inflamed atherosclerotic plaques, as well as in their homing to non-inflamed tissues, where they can differentiate into dendritic cells. CX3CR1 also promotes cell survival, plays a key role in brain microglia, synapse maturation and regulation of inflammatory response in the central nervous system, it acts as a negative regulator of angiogenesis, and serves as an important regulator of the gut microbiota by controlling immunity to intestinal bacteria and fungi.
Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μl reagent / 100 μl of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
|
There are currently no product reviews
|
.png "ACE2/HEK293 Stable Cell Line")
