Anti-Mouse LPAM-1 Azide Free Antibody (Clone : DATK32)
|Format :||Azide Free|
|Amount :||0.1 mg|
|Isotype :||Rat IgG2a kappa|
|Purification :||Purified by protein-A affinity chromatography|
|Content :||1 mg/ml
Formulation : Phosphate buffered saline (PBS) solution with 15 mM sodium azide
|Storage condition :||Store at 2-8°C. Do not freeze.|
|Gene ID :||16421|
|Alternative Name :||Integrin alpha 4 beta 7, CD49d / Ly69|
|Immunogen Information :||TK1 cells|
Integrin alpha 4 / beta 7 (CD49d / Ly69) , also known as LPAM-1 (Lymphocyte Peyer´s patch adhesion molecule 1), is a heterodimeric (150 kDa / 130 kDa) integrin complex which mediates lymphocyte homing to Peyer´s patch high endothelial venules and to the intestinal lamina propria. It is expressed primarily on mucosal lymphocytes, but is also present on NK cells and eosinophils. Ligands of LPAM-1 are MAdCAM-1, VCAM-1, and fibronectin, but the alpha 4 subunit (CD49d) can mediate also homotypic adhesion.
Specificity : The rat monoclonal antibody DATK32 recognizes an extracellular epitope of integrin alpha 4 (CD49d) and integrin beta7 (Ly69) components of mouse LPAM-1 complex, which is expressed on the majority of peripheral lymphocytes, as well as on subsets of thymocytes and bone marrow cells.