Anti-Mouse LPAM-1 Azide Free Antibody (Clone : DATK32)
Figure 1 : Flow cytometry surface staining pattern of murine splenocyte suspension stained using anti-mouse LPAM-1 (DATK32) purified antibody (concentration in sample 2 µg/ml) DAR APC.
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| Format : | Azide Free |
| Amount : | 0.1 mg |
| Isotype : | Rat IgG2a kappa |
| Purification : | Purified by protein-A affinity chromatography |
| Content : | 1 mg/ml Formulation : Phosphate buffered saline (PBS) solution with 15 mM sodium azide |
| Storage condition : | Store at 2-8°C. Do not freeze. |
| Gene : | Itgb7 |
| Gene ID : | 16421 |
| Alternative Name : | Integrin alpha 4 beta 7, CD49d / Ly69 |
| Immunogen Information : | TK1 cells |
Integrin alpha 4 / beta 7 (CD49d / Ly69) , also known as LPAM-1 (Lymphocyte Peyer´s patch adhesion molecule 1), is a heterodimeric (150 kDa / 130 kDa) integrin complex which mediates lymphocyte homing to Peyer´s patch high endothelial venules and to the intestinal lamina propria. It is expressed primarily on mucosal lymphocytes, but is also present on NK cells and eosinophils. Ligands of LPAM-1 are MAdCAM-1, VCAM-1, and fibronectin, but the alpha 4 subunit (CD49d) can mediate also homotypic adhesion.
Specificity : The rat monoclonal antibody DATK32 recognizes an extracellular epitope of integrin alpha 4 (CD49d) and integrin beta7 (Ly69) components of mouse LPAM-1 complex, which is expressed on the majority of peripheral lymphocytes, as well as on subsets of thymocytes and bone marrow cells.
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