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  7. Anti-MSH2 Monoclonal Antibody (Clone:IHC410)

Anti-MSH2 Monoclonal Antibody (Clone:IHC410)

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Figure 1: Immunohistochemical analysis of MSH2 (Clone: IHC410) on Esophagus

Anti-MSH2 Monoclonal Antibody (Clone:IHC410)

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Product code: 44-1044

Clone name : IHC410
Clonality : Monoclonal
Application : IHC
Reactivity : Human

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  •  0.5 ml

  • $288.00 

  • $525.00 

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Format : Purified
Amount : 0.5 ml
Isotype : Mouse IgG2b
Purification : Protein A/G Chromatography
Content : Tris Buffer, pH 7.3 - 7.7, with 1% BSA and <0.1% Sodium Azide
Storage condition : Store at 2°C - 8°C. Do not freeze.
Gene : MSH2
Gene ID : 4436
Uniprot ID : P43246
Immunogen Information : Recombinant Human MSH2

"MutS Homolog 2 (MSH2) is a protein involved in the mismatch-repair pathway. This protein is commonly associated with hereditary non-polyposis colorectal cancer, and mutations in this gene are correlated with the development of sporadic colorectal carcinoma. Expression levels of MSH2 are abnormally low in a high percentage of patients with microsatellite instability, as well as endometrial and ovarian cancers. Use of Anti-MSH2 is optimized when paired in an IHC panel with antibodies against MSH6, MLH1, and PMS2. Reports have shown Anti-MSH2 to be useful in the detection of the protein in a number of normal and neoplastic tissues, and for identifying a loss of MSH2 in tumors that are microsatellite-unstable."

Recommended dilutions: Immunohistochemical analysis: 1:100 - 1:200. However, this need to be optimized based on the research applications.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Nucleus
Post transnational modification: Phosphorylated by PRKCZ, which may prevent MutS alpha degradation by the ubiquitin-proteasome pathway.
Tissue Specificity: Ubiquitously expressed.
BioGrid: 110573. 134 interactions.
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Anti-MSH2 Monoclonal Antibody (Clone:IHC410)

Product code: 44-1044
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