Anti-MSH2 Monoclonal Antibody (Clone:IHC410)
Figure 1: Immunohistochemical analysis of MSH2 (Clone: IHC410) on Esophagus
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| Format : | Purified |
| Amount : | 0.5 ml |
| Isotype : | Mouse IgG2b |
| Purification : | Protein A/G Chromatography |
| Content : | Tris Buffer, pH 7.3 - 7.7, with 1% BSA and <0.1% Sodium Azide |
| Storage condition : | Store at 2°C - 8°C. Do not freeze. |
"MutS Homolog 2 (MSH2) is a protein involved in the mismatch-repair pathway. This protein is commonly associated with hereditary non-polyposis colorectal cancer, and mutations in this gene are correlated with the development of sporadic colorectal carcinoma. Expression levels of MSH2 are abnormally low in a high percentage of patients with microsatellite instability, as well as endometrial and ovarian cancers. Use of Anti-MSH2 is optimized when paired in an IHC panel with antibodies against MSH6, MLH1, and PMS2. Reports have shown Anti-MSH2 to be useful in the detection of the protein in a number of normal and neoplastic tissues, and for identifying a loss of MSH2 in tumors that are microsatellite-unstable."
Recommended dilutions: Immunohistochemical analysis: 1:100 - 1:200. However, this need to be optimized based on the research applications.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Nucleus |
| Post transnational modification: | Phosphorylated by PRKCZ, which may prevent MutS alpha degradation by the ubiquitin-proteasome pathway. |
| Tissue Specificity: | Ubiquitously expressed. |
| BioGrid: | 110573. 134 interactions. |
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