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  7. Anti-ACTH (Adrenocorticotrophic Hormone) (C-Terminal) (Pituitary Marker) Monoclonal Antibody(Clone: SPM501)

Anti-ACTH (Adrenocorticotrophic Hormone) (C-Terminal) (Pituitary Marker) Monoclonal Antibody(Clone: SPM501)

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Fig. 1: Formalin-fixed, paraffin-embedded human Pituitary stained with ACTH Monoclonal Antibody (SPM501).

Anti-ACTH (Adrenocorticotrophic Hormone) (C-Terminal) (Pituitary Marker) Monoclonal Antibody(Clone: SPM501)

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Product code: 36-2958

Clone name : SPM501
Clonality : Monoclonal
Application : ELISA, FACS, IF, IHC
Reactivity : Human

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  •  100 µg

  • $199.00 

  • $459.00 

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  • Product Info
  • Antigen Details
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Amount : 100 µg
Isotype : Mouse IgG1, kappa
Content : 200 µg/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Storage condition : Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous.
Gene : POMC
Gene ID : 5443
Uniprot ID : P01189
Alternative Name : Adrenocorticotropin; alpha or beta or gamma Melanocyte Stimulating Hormone (MSH) or Melanotropin; beta-Endorphin; beta or gamma Lipotropin (LPH); CLIP; Met Enkephalin; POC; POMC
Immunogen Information : Synthetic peptide corresponding to aa25-39 of human ACTH (NGAEDESAEAFPLEF)
ACTH (same as Corticotropin) is a 39 amino acid active peptide produced by the anterior pituitary. This MAb is specific to CLIP (aa25-39 of ACTH); does not react with Synacthen (aa1-24 of ACTH). POMC (pro-opiomelanocortin or corticotropin-lipotropin) is a 267 amino acid polypeptide hormone precursor that goes throµgh extensive, tissue-specific posttranslational processing by convertases. POMC is cleaved into ten hormone chains named NPP, ACTH, alpha-MSH (Melanocyte Stimulating Hormone), beta-MSH, gamma-MSH, CLIP (corticotropin-like intermediary peptide), Lipotropin-beta, Lipotropin-gamma, beta-endorphin and Met-enkephalin. ACTH is also produced by cells of immune system (T-cells, B-cells, and macrophages) in response to stimuli associated with stress. Anti-ACTH is a useful marker in classification of pituitary tumors and the study of pituitary disease. It reacts with ACTH-producing cells (corticotrophs).It also may react with other tumors (e.g. some small cell carcinomas of the lung) causing paraneoplastic syndromes by secreting ACTH. '

ELISA (For coating, order Ab without BSA); Flow Cytometry (0.5-1µg/million cells); Immunofluorescence (1-2µg/ml); Immunohistochemistry (Formalin-fixed) (0.5-1µg/ml for 30 minutes at RT) (Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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Anti-ACTH (Adrenocorticotrophic Hormone) (C-Terminal) (Pituitary Marker) Monoclonal Antibody(Clone: SPM501)

Product code: 36-2958
*specify in mg or ml

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