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  7. Anti-p53 Monoclonal Antibody (Clone:IHC053)

Anti-p53 Monoclonal Antibody (Clone:IHC053)

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Figure 1: Immunohistochemical analysis of p53 (Clone: IHC053) on Colon Cancer

Anti-p53 Monoclonal Antibody (Clone:IHC053)

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Product code: 44-1060

Clone name : IHC053
Clonality : Monoclonal
Application : IHC
Reactivity : Human

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  •   0.1 ml

  •  0.5 ml

  • $275.00 

  • $438.00 

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Format : Purified
Amount : 0.5 ml
Isotype : Mouse IgG2b
Purification : Protein A/G Chromatography
Content : Tris Buffer, pH 7.3 - 7.7, with 1% BSA and <0.1% Sodium Azide
Storage condition : Store at 2°C - 8°C. Do not freeze.
Gene : TP53
Gene ID : 7157
Uniprot ID : P04637
Alternative Name : TP53, P53
Immunogen Information : Recombinant Human p53

p53, also known as tumor protein 53 or TP53, is a tumor suppressor and transcription factor that functions in a number of anti-cancer activities including DNA repair, cell-cycle arrest, and apoptosis in response to DNA damage or other stressors. Mutations in p53 are linked to a number of malignant tumors, including those of the breast, ovarian, bladder, colon, lung, and melanoma. Anti-p53 staining has been used to detect intratubular germ cell neoplasia, and also to distinguish between uterine serous carcinoma and endometrioid carcinoma.

Recommended dilutions: Immunohistochemical analysis: 1:100 - 1:200. However, this need to be optimized based on the research applications.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Cytoplasm
Post transnational modification: Sumoylated with SUMO1. Sumoylated at Lys-386 by UBC9.
Tissue Specificity: Ubiquitous. Isoforms are expressed in a wide range of normal tissues but in a tissue-dependent manner. Isoform 2 is expressed in most normal tissues but is not detected in brain, lung, prostate, muscle, fetal brain, spinal cord and fetal liver. Isoform 3 is expressed in most normal tissues but is not detected in lung, spleen, testis, fetal brain, spinal cord and fetal liver. Isoform 7 is expressed in most normal tissues but is not detected in prostate, uterus, skeletal muscle and breast. Isoform 8 is detected only in colon, bone marrow, testis, fetal brain and intestine. Isoform 9 is expressed in most normal tissues but is not detected in brain, heart, lung, fetal liver, salivary gland, breast or intestine.
BioGrid: 113010. 1093 interactions.
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Anti-p53 Monoclonal Antibody (Clone:IHC053)

Product code: 44-1060
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