Polyclonal Antibody to Beta Tubulin
Tubulin is one of several members of a small family of globular proteins and is the major constituent of microtubules. The most common members of the tubulin family are alpha-tubulin and beta-tubulin. It appears to play an important role in the formation of platelet. It is involved in the pathogenesis of Cortical dysplasia, complex, with other brain malformations 6 (CDCBM6) and distal hereditary motor neuropathy, type 2. Ubiquitously expressed with highest levels in spleen, thymus and immature brain. It is expressed exclusively in megakaryocytes and platelets in humans.
|Purification :||Protein A Chromatography|
|Content :||25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.|
|Storage condition :||Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.|
Western blot analysis: 4-6 µg/ml
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
|Post transnational modification:||Phosphorylated on Ser-172 by CDK1 during the cell cycle, from metaphase to telophase, but not in interphase. This phosphorylation inhibits tubulin incorporation into microtubules.|
|Tissue Specificity:||High expression in brain, where it represents 30% of all beta-tubulins.|
|BioGrid:||113131. 128 interactions.|