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  7. Anti-p53 Tumor Suppressor Protein Monoclonal Antibody(Clone: PAb240)

Anti-p53 Tumor Suppressor Protein Monoclonal Antibody(Clone: PAb240)

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Fig. 1: SDS-PAGE Analysis Purified p53 Mouse Monoclonal Antibody (PAb240). Confirmation of Integrity and Purity of Antibody.

Anti-p53 Tumor Suppressor Protein Monoclonal Antibody(Clone: PAb240)
Anti-p53 Tumor Suppressor Protein Monoclonal Antibody(Clone: PAb240)

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Fig. 1: SDS-PAGE Analysis Purified p53 Mouse Monoclonal Antibody (PAb240). Confirmation of Integrity and Purity of Antibody.
Fig. 2: Analysis of Protein Array containing more than 19,000 full-length human proteins using p53 Mouse Monoclonal Antibody (PAb240). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (Monoclonal Antibody) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a Monoclonal Antibody to its intended target. A Monoclonal Antibody is considered to specific to its intended target, if the Monoclonal Antibody has an S-score of at least 2.5. For example, if a Monoclonal Antibody binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that Monoclonal Antibody to protein X is equal to 29.

Product code: 36-3295

Clone name : PAb240
Clonality : Monoclonal
Application : ELISA
Reactivity : Human, Mouse, Rat

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  •   20 µg

  •  100 µg

  • $199.00 

  • $459.00 

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  • Antigen Details
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Amount : 100 µg
Isotype : Mouse IgG1, kappa
Content : 200 µg/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Storage condition : Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous.
Gene : TP53
Gene ID : 7157
Uniprot ID : P04637
Alternative Name : Antigen NY-CO-13, BCC7, Cellular Tumor Antigen p53, LFS1, TP53, Transformation Related Protein 53 (TRP53), Tumor Protein p53, Tumor Suppressor p53
Immunogen Information : Gel-Purified p53-beta-galactosidase fusion protein containing murine p53 from aa 14-389
The specificity of this monoclonal antibody to its intended target was tested by HuProtTM Array, containing more than 19,000, full-length human proteins. PAb240 binds to the C-terminus (aa213-217) of both wild type and mutated p53. Mutation and/or allelic loss of p53 is one of the causes of a variety of mesenchymal and epithelial tumors. If it occurs in the germ line, such tumors run in families. p53 Binds to a DNA consensus sequence, the p53 response element, and it regulates normal cell growth cycle events by activating transcription of genes, involved either in progression throµgh the cycle, or causing arrest in G1 when the genome is damaged. In most transformed and tumor cells the concentration of p53 is increased 51000 fold over the minute concentrations (1000 molecules cell) in normal cells, principally due to the increased half-life (4 h) compared to that of the wild-type (20 min). p53 Localizes in the nucleus, but is detectable at the plasma membrane during mitosis and when certain mutations modulate cytoplasmic/nuclear distribution. p53 Is the most commonly mutated gene in spontaneously occurring human cancers. Mutations arise with an average frequency of 70% but incidence varies from zero in carcinoid lung tumors to 97% in primary melanomas. High concentrations of p53 protein are transiently expressed in human epidermis and superficial dermal fibroblasts following mild ultraviolet irradiation.

ELISA (For coating, order Ab without BSA)Optimal dilution for a specific application should be determined.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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Anti-p53 Tumor Suppressor Protein Monoclonal Antibody(Clone: PAb240)

Product code: 36-3295
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