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    7. Anti-PD-L1 Rabbit Monoclonal Antibody (Clone:IHC411)-Ready to Use

    Anti-PD-L1 Rabbit Monoclonal Antibody (Clone:IHC411)-Ready to Use

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    Figure 1: Immunohistochemical analysis of PD-L1 (Clone: IHC411) on Lung

    Anti-PD-L1 Rabbit Monoclonal Antibody (Clone:IHC411)-Ready to Use

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    Product code: 44-1070

    Clone name : IHC411
    Clonality : Monoclonal
    Application : IHC
    Reactivity : Human

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    For estimated delivery dates, please contact us at support@abeomics.com

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    7 ml
    $357.00  $285.60 

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    For estimated delivery dates, please contact us at support@abeomics.com

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    • Product Info
    • Antigen Details
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    Amount : 7 ml
    Isotype : Rabbit IgG
    Purification : Protein A/G Chromatography
    Content : Tris Buffer, pH 7.3 - 7.7, with 1% BSA and <0.1% Sodium Azide
    Storage condition : Store at 2°C - 8°C. Do not freeze.
    Gene : CD274
    Gene ID : 29126
    Uniprot ID : Q9NZQ7
    Immunogen Information : Recombinant Human PD-L1

    "Programmed Death-Ligand 1 (PD-L1), also known as CD274 or B7 Homolog 1 (B7-H1), is a transmembrane protein involved in suppressing the immune system and rendering tumor cells resistant to CD8+ T cell-mediated lysis through binding of the Programmed Death-1 (PD-1) receptor. Overexpression of PD-L1 may allow cancer cells to evade the actions of the host immune system. In renal cell carcinoma, upregulation of PD-L1 has been linked to increased tumor aggressiveness and risk of death, and, in ovarian cancer, higher expression of this protein has lead to significantly poorer prognosis. PD-L1 has also been linked to systemic lupus erythematosus and cutaneous melanoma. When considered in adjunct with CD8+ tumor-infiltrating lymphocyte density, expression levels of PD-L1 may be a useful predictor of multiple cancer types, including stage III non-small cell lung cancer, hormone receptor negative breast cancer, and sentinel lymph node melanoma."

    This product is available in ready to use format, hence no dilution is required.

    For Research Use Only. Not for use in diagnostic/therapeutics procedures.

    Subcellular location: Endomembrane system
    Post transnational modification: Ubiquitinated; STUB1 likely mediates polyubiquitination of PD-L1/CD274 triggering its degradation.
    Tissue Specificity: Highly expressed in the heart, skeletal muscle, placenta and lung. Weakly expressed in the thymus, spleen, kidney and liver. Expressed on activated T- and B-cells, dendritic cells, keratinocytes and monocytes.
    BioGrid: 118891. 48 interactions.
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    Anti-PD-L1 Rabbit Monoclonal Antibody (Clone:IHC411)-Ready to Use

    Product code: 44-1070
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