Anti-PD-L2 / PDCD1LG2 / CD273 Monoclonal Antibody(Clone: PDL2/1850)
Fig. 1: SDS-PAGE Analysis Purified PD-L2 Mouse Monoclonal Antibody (Z64P2D3*H4). Confirmation of Purity and Integrity of Antibody.
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| Amount : | 100 µg |
| Isotype : | Mouse IgG1, kappa |
| Content : | 200 µg/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
| Storage condition : | Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. |
| Gene : | PDCD1LG2 |
| Gene ID : | 80380 |
| Uniprot ID : | Q9Q51 |
| Alternative Name : | B7 dendritic cell molecule; B7-DC; B7DC; Btdc; Butyrophilin B7DC; CD273; PD-L2; PDCD1L2; PDCD1LG2; PDL2; Programmed death ligand 2 |
| Immunogen Information : | Recombinant fragment (around aa 27-220) of human PD-L2 protein (exact sequence is proprietary) |
Recognizes a protein of about 31kDa, which is identified as PD-L2 (same as PDCD1LG2). Engagement of CD28 by B7-1 (CD80) or B7-2 (CD86) in the presence of antigen promotes T cell proliferation, cytokine production, differentiation of effector T cells and the induction of Bcl-x, a promoter of T cell survival. Conversely, engagement of CTLA4 by B7-1 or B7-2 may inhibit proliferation and IL-2 production. PD-L2 does not bind CD28, cytotoxic T lymphocyte A4 or ICOS (inducible co-stimulator). The constitutive expression of PD-L1 and PD-L2 on parenchymal cells of heart, lung and kidney sµggests that the Pdcd-1-Pdcd-L system could provide unique negative signaling to help prevent autoimmune disease.
Flow Cytometry (0.5-1µg/million cells),Optimal dilution for a specific application should be determined.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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