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  7. Anti-PDE8a Monoclonal Antibody (Clone:EM-52)

Anti-PDE8a Monoclonal Antibody (Clone:EM-52)

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Figure 1: Western blotting analysis (reducing conditions) of PDE8a in HEK293T/17-PDE8a transfectants using mouse monoclonal antibody EM-52.

Anti-PDE8a Monoclonal Antibody (Clone:EM-52)

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Product code: 30-1511

Clone name : EM-52
Clonality : Monoclonal
Application : WB
Reactivity : Human

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0.1 mg
$383.00 

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Format : Purified
Amount : 0.1 mg
Isotype : Mouse IgG1
Purification : Purified by protein-A affinity chromatography
Storage condition : Store at 2-8°C. Do not freeze.
Gene : PDE8A
Gene ID : 5151
Uniprot ID : O60658
Alternative Name : PDE8A
Immunogen Information : Human PDE8a

PDE8a (high affinity cAMP-specific and IBMX-insensitive 3´,5´-cyclic phosphodiesterase 8 A) is a cyclic nucleotide phosphodiesterase, which hydrolyzes cAMP, an important regulator and mediator of multiple cellular responses to extracellular signals. It is expressed in a wide variety of tissues including testis, ovary, small intestine, and colon. It is not expressed e.g. in thymus. PDE8a is composed of C-terminal catalytic domain containing two putative divalent metal sites and an N-terminal regulatory domain.

Western blotting: Recommended dilution: 1-2 μg/ml.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Post transnational modification: Phosphorylated at Ser-359 by PKA under elevated cAMP conditions, this enhances catalytic activity.
Tissue Specificity: Expressed in most tissues except thymus and peripheral blood leukocytes. Highest levels in testis, ovary, small intestine and colon.
BioGrid: 111177. 4 interactions.
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Anti-PDE8a Monoclonal Antibody (Clone:EM-52)

Product code: 30-1511
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